In this article the authors created an interaction map of proteins involved in colorectal cancer to look for driver vs. non-driver genes. That is they wanted to see if they could determine what genes are more likely to drive the development and progression in colorectal cancer and which are present in altered states but not necessarily driving disease progression.

The Human Immunodeficiency Virus (HIV) infects approximately 40 million people globally, and one million people die every year from Acquired Immune Deficiency Syndrome (AIDS)-related illnesses. This study examined the interactions between the HIV-1 envelope glycoprotein gp120 and the human lymphocyte receptor integrin α4β7, the putative first long-range receptor for the envelope glycoprotein of the virus in mucosal tissues. Presented data support the claim that the V1 loop is involved in the binding between α4β7 and the HIV-1 envelope glycoprotein through molecular dockings.

Here, seeking to better understand on the effects of social isolation during the COVID-19 pandemic, the authors used a survey during April and May of 2020 of participants primarily in Long Island, NY to assess the physical and mental health of the general population. They found negative impacts to physical health and increases in depressive symptoms and feelings of loneliness across all groups. More significant increases in negative mental health symptoms were observed in younger age groups and amongst women.

With the COVID-19 pandemic necessitating the transition to remote learning, disruption to daily school routine has impacted educational experiences on a global scale. As a result, it has potentially worsened reading achievement gaps typically exacerbated by long summer months. To address literacy skill retention and pandemic-induced social isolation, the non-profit organization ByKids4Kids has created a reading program, “Kindles4Covid Virtual Reading Buddies Program,” to instill a structure for youth to read together and connect with the convenience of Amazon Kindle devices. In this article, the authors determine the efficacy of their invaluable program by assessing changes in reading frequency and self-reported connectedness among program participants.

Here, through protein-ligand docking, the authors investigated the effect of the interaction of emodin with serine/threonine kinases, a subclass of kinases that is overexpressed in many cancers, which is implicated in phosphorylation cascades. Through molecular dynamics theyfound that emodin forms favorable interactions with chitosan and chitosan PEG (polyethylene glycol) copolymers, which could aid in loading drugs into nanoparticles (NPs) for targeted delivery to cancerous tissue. Both polymers demonstrated reasonable entrapment efficiencies, which encourages experimental exploration of emodin through targeted drug delivery vehicles and their anticancer activity.

Large corporations often are known for their financial power, but what social and environmental power and conscious do they have? The more responsible corporations are in relation to environmental, social, and governance criteria the better they do fiscally.

Here, seeking to understand how the COVID-19 pandemic affected the social interactions of junior high school students, the authors surveyed students, teachers, and parents. Contrary to their initial hypotheses, the authors found positive correlation between increased virtual contact during social isolation and in-person conflict and disregard for social norms after the pandemic. While the authors identified the limitations of their study, they suggest that further research into the effect of online interactions is becoming increasingly important.

Here, recognizing the potential harmful effects of algal blooms, the authors used satellite images to detect algal blooms in water bodies in Wyoming based on their reflectance of near infrared light. They found that remote monitoring in this way may provide a useful tool in providing early warning and advisories to people who may live in close proximity.

Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.

Molecular dynamics (MD) simulations are a great tool to model and study complex biological systems. In this paper, the authors use MD simulations to construct and simulate a model of the periplasmic space, the peptidoglycan layer and its associated proteins, in an Escherichia coli cell.