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In this experiment, the authors modify the heat equation to account for imperfect insulation during heat transfer and compare it to experimental data to determine which is more accurate.

The authors assess a genetic variant within a well-known interaction partner of huntingtin that has been linked to modifying the age of onset of Huntington's disease.

This paper looks at the antibacterial and toxic effects of silver nanoparticles (AgNPs) on Escherichia coli bacteria and Drosophila melanogaster fruit flies. They modified the AgNPs size, concentration, and surface coating to determine the effects on each of the organisms. For both organisms, increased AgNP concentration demonstrated increased toxicity but particle size and surface coating had opposing effects.

Andrographolide, a natural compound with anti-inflammatory, antidepressant, and anti-cancer properties, can be chemically modified by adding an acetonide group to form andrographolide acetonide, which is more potent and acts as a pH-dependent prodrug. Researchers investigated the hydrolysis of this acetonide group under mildly acidic conditions.

Dust accumulation on solar panels can reduce electricity output by 20–50%, posing a major challenge for solar energy collection. Instead of altering panel design, we explored a simpler approach by modifying surface energy through nanotexturing, predicting that hydrophobic surfaces would repel both water and dust. This study found that treating glass and silicone surfaces with potassium hydroxide (KOH) for 13 and 10 minutes, respectively, created optimal nanotextures (445 nm for glass, 205 nm for silicone), significantly reducing dirt accumulation and improving solar energy capture.

In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.

Thymoquinone is a compound of great therapeutic potential and scientific interest. However, its clinical administration and synthetic modifications are greatly limited by its instability in the presence of light. This study employed quantitative 1H nuclear magnetic resonance (NMR) spectroscopy to identify the effect of solvation on the degradation of thymoquinone under ultraviolet light (UV). It found that the rate of degradation is highly solvent dependent occurs maximally in chloroform.

Here, recognizing the recognizing the growing threat of non-biodegradable plastic waste, the authors investigated the ability to use a modified enzyme identified in bacteria to decompose polyethylene terephthalate (PET). They used simulations to screen and identify an optimized enzyme based on machine learning models. Ultimately, they identified a potential mutant PETases capable of decomposing PET with improved thermal stability.

The purpose of this study was to test devices installed on a gabled roof to see which reduced the actual uplift forces best. Three gabled birdhouse roofs were each modified with different mitigation devices: a rounded edge, a barrier shape, or an airfoil. The barrier edge had no significant effect on the time for the roof to blow off. The addition of airfoil devices on roofs, specifically in areas that are prone to hurricanes such as Florida, could keep roofs in place during hurricanes, thus reducing insurance bills, overall damage costs, and the loss of lives.

In this article the authors address the complex and life quality-diminishing neurodegenerative disease known as Parkinson's. Although genetic and/or environmental factors contribute to the etiology of the disease, the diagnostic symptoms are the same. By genetically modifying fruit flies to exhibit symptoms of Parkinson's disease, they investigate whether drugs that inhibit mitochondrial calcium uptake or activate the lysosomal degradation of proteins could improve the symptoms of Parkinson's these flies exhibit. The authors report the most promising outcome to be that when both types of drugs were used together. Their data provides encouraging evidence to support further investigation of the utility of such drugs in the treatment of human Parkinson's patients.