Here, authors characterize how different acoustics affect the properties of a Bunsen-type flame.
Read More...Investigation of Bunsen-type Premixed Flame Response to Acoustic Excitation: Temperature and Flame Profile
Here, authors characterize how different acoustics affect the properties of a Bunsen-type flame.
Read More...Applying centrality analysis on a protein interaction network to predict colorectal cancer driver genes
In this article the authors created an interaction map of proteins involved in colorectal cancer to look for driver vs. non-driver genes. That is they wanted to see if they could determine what genes are more likely to drive the development and progression in colorectal cancer and which are present in altered states but not necessarily driving disease progression.
Read More...Plasmid Variance and Nutrient Regulation of Bioluminescence Genes
Numerous organisms, including the marine bacterium Aliivibrio fischeri, produce light. This bioluminescence is involved in many important symbioses and may one day be an important source of light for humans. In this study, the authors investigated ways to increase bioluminescence production from the model organism E. coli.
Read More...The effects of the cancer metastasis promoting gene CD151 in E. coli
The independent effects of metastasis-promoting gene CD151 in the process of metastasis are not known. This study aimed to isolate CD151 to discover what its role in metastasis would be uninfluenced by potential interactions with other components and pathways in human cells. Results showed that CD151 significantly increased the adhesion of the cells and decreased their motility. Thus, it may be that CD151 is upregulated in cancer cells for the last step of metastasis, and it increases the chances of success of metastasis by aiding in implantation of the cancer cells. Targeting CD151 in chemotherapeutic modalities could therefore potentially slow or prevent metastasis.
Read More...Application of gene therapy for reversing T-cell dysfunction in cancer
Since cancer cells inhibit T-cell activity, the authors investigated a method to reverse T-cell disfunction with gene therapy, so that the T-cells would become effective once again in fighting cancer cells. They used the inhibition of proprotein convertases (PCSK1) in T cells and programmed death-ligand 1 (CD274) in cancer cells. They observed the recovery of IL-2 expression in Jurkat cells, with increased recovery noted in a co-culture sample. This study suggests a novel strategy to reactivate T cells.
Read More...RNAi-based Gene Therapy Targeting ZGPAT Promotes EGF-dependent Wound Healing
Wound-healing involves a sequence of events, such as inflammation, proliferation, and migration of different cell types like fibroblasts. Zinc Finger CCCH-type with G-Patch Domain Containing Protein (ZGPAT), encodes a protein that has its main role as a transcription repressor by binding to a specific DNA sequence. The aim of the study was to find out whether inhibiting ZGPAT will expedite the wound healing process by accelerating cell migration. This treatment strategy can provide a key to the development of wound healing strategies in medicine and cellular biology.
Read More...String analysis of exon 10 of the CFTR gene and the use of Bioinformatics in determination of the most accurate DNA indicator for CF prediction
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene. In this paper, the authors attempt to identify variations in stretches of up to 8 nucleotides in the protein-coding portions of the CFTR gene that are associated with disease development. This would allow screening of newborns or even fetuses in utero to determine the likelihood they develop cystic fibrosis.
Read More...The Effect of the Human MeCP2 gene on Drosophila melanogaster behavior and p53 inhibition as a model for Rett Syndrome
In this study, the authors observe if the symptoms of Rett Syndrome, a neurodegenerative disease in humans, are reflected in Drosophila melanogaster. This was achieved by differentiating the behavior and physical aspects of wild-type flies from flies expressing the full-length MeCP2 gene and the mutated MeCP2 gene (R106W). After conducting these experiments, some of the Rett Syndrome symptoms were recapitulated in Drosophila, and a subset of those were partially ameliorated by the introduction of pifithrin-alpha.
Read More...The extent to which storefront alcohol advertising differs by community profile in Michigan
Here, recognizing that alcohol manufacturers may target ethnic minorities and youths with specific forms of advertisements based on previous studies, the authors considered how alcohol storefronts differ depending on the community they are located in. Specifically, they looked at differences between Metro-Dtroit suburban communities of high- and low-incomes. They found that alcohol stores in the low-income areas had more and larger alcohol and malt liquor advertisements per store along with being within 1,000 feet of a school.
Read More...Characterization and Phylogenetic Analysis of the Cytochrome B Gene (cytb) in Salvelinus fontinalis, Salmo trutta and Salvelinus fontinalis X Salmo trutta Within the Lake Champlain Basin
Recent declines in the brook trout population of the Lake Champlain Basin have made the genetic screening of this and other trout species of utmost importance. In this study, the authors collected and analyzed 21 DNA samples from Lake Champlain Basin trout populations and performed a phylogenetic analysis on these samples using the cytochrome b gene. The findings presented in this study may influence future habitat decisions in this region.
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