The authors looked at the primary structure of lignin peroxidase in an attempt to identify mutations that would improve both the stability and solubility of the peroxidase protein. The goal is to engineer peroxidase enzymes that are stable to help break down polymers, such as PVC, into monomers that can be reused instead of going to landfills.
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Digestion products of bread and cheese cause addictive behavior in a planaria model
The authors looked at two peptides, gluteomorphin and casomorphin, that are present after the digestion of bread and cheese. As these peptides can bind opioid receptors the authors want to know if they could be addictive in the same way as conventional opioids (i.e., morphine) are known to be. Their results in a planaria model suggest that both of these peptides are addictive.
Read More...Intra and interspecies control of bacterial growth through extracellular extracts
The study discusses the relationship between bacterial species and the human gut microbiome, emphasizing the role of quorum sensing molecules in bacterial communication and its implications for health. Authors investigated the impact of bacterial supernatants from Escherichia coli (E. coli) on the growth of new E. coli and Enterobacter aerogenes (E. aerogenes) cultures.
Read More...The frequency and psychological effects of name mispronunciation in an independent school
The authors survey high school students regarding the frequency of microaggressions such as name mispronunciation.
Read More...A novel approach for predicting Alzheimer’s disease using machine learning on DNA methylation in blood
Here, recognizing the difficulty associated with tracking the progression of dementia, the authors used machine learning models to predict between the presence of cognitive normalcy, mild cognitive impairment, and Alzheimer's Disease, based on blood DNA methylation levels, sex, and age. With four machine learning models and two dataset dimensionality reduction methods they achieved an accuracy of 53.33%.
Read More...Analysis of ultraviolet light as a bactericide of gram-negative bacteria in Cladophora macroalgae extracts
Here, the authors sought to use Cladophora macroalgae as a possible antibiotic to address the growing threat of antibiotic resistance in pathogenic bacteria. However, when they observed algae extracts to be greatly contaminated with gram-negative bacteria, they adapted to explore the ability to use ultraviolet light as a bactericide. They found that treatment with ultraviolet light had a significant effect.
Read More...A Crossover Study Comparing the Effect of a Processed vs. Unprocessed Diet on the Spatial Learning Ability of Zebrafish
The authors compared the short-term effects of processed versus unprocessed food on spatial learning and survival in zebrafish, given the large public concern regarding processed foods. By randomly assigning zebrafish to a diet of brine shrimp flakes (processed) or live brine shrimp (unprocessed), the authors show while there is no immediate effect on a fish's decision process between the two diets, there are significant correlations between improved learning and stress response with the unprocessed diet.
Read More...Spectroscopic Kinetic Monitoring and Molecular Dynamics Simulations of Biocatalytic Ester Hydrolysis in Non-Aqueous Solvent
Lipases are a common class of enzymes that catalyze the breakdown of lipids. Here the authors characterize the the activity of pancreatic lipase in different organic solvents using a choloremetric assay, as well as using molecular dynamic simulations. They report that the activity of pancreatic lipase in 5% methanol is more than 25% higher than in water, despite enzyme stability being comparable in both solvents. This suggests that, for industrial applications, using pancreatic lipase in 5% methanol solution might increase yield, compared to just water.
Read More...The Effect of Different Fructose Diets on the Lifespan of C. elegans
High-fructose diets consumed widely in modern societies predisposes to metabolic diseases such as diabetes. Using the worm C. elegans, the authors of this study investigated the effect of fructose on the worm's survival rates. They found that worms fed 15% fructose had a lower life expectancy than those on a fructose-free diet. These results suggest that, like in humans, fructose has a negative effect on worm survival, which makes them an easy, attractive model to study the effects of fructose on health.
Read More...Behavioral Longevity: The Impact of Smoking, Alcohol Consumption, and Obesity on Life Expectancy
In this article, the authors look into what is already known about the factor affecting longevity and determine the importance of behavioral factors including alcohol consumption, smoking, and obesity on longevity. The authors quantify data from over 150 countries and, interestingly, find that the impact each factor has on longevity is at least in part dependent on the country's economic development status. Overall, they conclude that an average person’s life expectancy can increase by more than 3 years if smoking and alcohol consumption is reduced by a half and weight is decreased by 10%.
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