Although the 5-year survival rate for colorectal cancer is below 10%, it increases to greater than 90% if it is diagnosed early. We hypothesized from our research that analyzing non-synonymous single nucleotide variants (SNVs) in a patient's exome sequence would be an indicator for high genetic risk of developing colorectal cancer.
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Evaluation of in vitro anti-inflammatory effect of PLAY® on UC-MSCs: A COX-2 expression study
The authors seek to accelerate wound healing by reducing inflammation with a cocktail containing growth factors and bioactive modulators.
Read More...Household spices and minerals as alternative disinfectants for mobile phones
In this study, the authors investigate the disinfectant potential of many household spices and minerals. More specifically, they test whether these compounds can be used to disinfect mobile phones after daily use with the hope of identifying environmentally-friendly cleaning options.
Read More...Uncovering mirror neurons’ molecular identity by single cell transcriptomics and microarray analysis
In this study, the authors use bioinformatic approaches to characterize the mirror neurons, which are active when performing and seeing certain actions. They also investigated whether mirror neuron impairment was connected to neural degenerative diseases and psychiatric disorders.
Read More...Pediatric probiotic culture survival study in acidic pH using an in vitro model
In this study, the authors investigate the effects of acidity on the survival of commercial probiotic Lovebug bacterial strains.
Read More...The sweetened actualities of neural membrane proteins: A computational structural analysis
Here, seeking to better understand the roles of glycans in the receptors of active sites of neuronal cells, the authors used molecular dynamics simulations to to uncover the dynamic nature of N-glycans on membrane proteins. The authors suggest the study of theinteractions of these membrane poreins could provide future potential therapeutic targets to treat mental diseases.
Read More...A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts
Oxidative damage and neuro-inflammation were the key pathways implicated in the pathogenesis of Alzheimer’s disease. In this study, 30 natural extracts from plant roots and leaves with extensive anti-inflammatory and anti-oxidative properties were consumed by Drosophila melanogaster. Several assays were performed to evaluate the efficacy of these combinational extracts on delaying the progression of Alzheimer’s disease. The experimental group showed increased motor activity, improved associative memory, and decreased lifespan decline relative to the control group.
Read More...Design and implementation of a cryptographically secure electronic voting infrastructure
In this study, the authors present proposed cryptographic controls for election sites with the hypothesis that this will mitigate risk and remediate vulnerabilities.
Read More...Effects of caffeine on muscle signals measured with sEMG signals
Here, the authors used surface electromyography to measure the effects of caffeine intake on the resting activity of muscles. They found a significant increase in the measured amplitude suggesting that caffeine intake increased the number of activated muscle fibers during rest. While previous research has focused on caffeine's effect on the contraction signals of muscles, this research suggests that its effects extend to even when a muscle is at rest.
Read More...Discovery of novel targets for diffuse large B-cell lymphoma
In this study, the authors identify new potential targets to treat advanced diffuse large B-cell lymphoma after treatment relapse and loss of CD19 expression.
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