Antibiotics are oftentimes used to treat mastitis (infection of the mammary gland) in dairy cows. Regulations require that milk from these cows be discarded until the infection has cleared and antibiotic residues are no longer detectable in the cow's milk. These regulations are in place to protect consumers and to help prevent the rise of antibiotic resistant bacteria. In this study, the authors test milk samples from 10 milk suppliers in the Greensboro, NC to see if they contain detectable levels of antibiotic residues.
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An in vitro comparative analysis of the growth factors present in FBS vs PLAY®
Here the authors performed a comparative analysis to investigate the viability of using PLAY® instead of fetal bovine serum (FBS) as a growth medium to culture cells with an enzyme-linked immunosorbent assay.
Read More...SpottingDiffusion: Using transfer learning to detect Latent Diffusion Model-synthesized images
Development of selective RAC1/KLRN inhibitors
Kalirin is a guanine nucleotide exchange factor (GEF) for the GTPase RAC1, linked to schizophrenia and Alzheimer’s Disease. It plays a crucial role in synaptic plasticity by regulating dendritic spine formation and actin cytoskeleton remodeling, which are essential for creating new synapses. Authors developed two novel compounds targeting kalirin, confirming that predictive modeling can indicate biological activity.
Read More...Mendelian randomization reveals shared genetic landscape in autism spectrum disorder and Alzheimer's disease
Autism Spectrum Disorder (ASD) and Alzheimer's Disease (AD) are distinct conditions, but research suggests a link, as individuals with ASD are 2.5 times more likely to develop AD. A study employing genome-wide association studies and Mendelian randomization revealed shared genetic factors, particularly in synaptic regulation pathways, that may increase the risk of AD in those with ASD. These findings provide insights into the genetic underpinnings connecting the two disorders.
Read More...Generation of a magnetic field on Mars
The authors propose and test a method that would allow for the generation of a magnetic field on Mars sufficient to support future colonization.
Read More...Vineyard vigilance: Harnessing deep learning for grapevine disease detection
Globally, the cultivation of 77.8 million tons of grapes each year underscores their significance in both diets and agriculture. However, grapevines face mounting threats from diseases such as black rot, Esca, and leaf blight. Traditional detection methods often lag, leading to reduced yields and poor fruit quality. To address this, authors used machine learning, specifically deep learning with Convolutional Neural Networks (CNNs), to enhance disease detection.
Read More...Identification of potential therapeutic targets for multiple myeloma by gene expression analysis
A central challenge of cancer therapy is identifying treatments that will effectively target cancer cells while minimizing effects on healthy cells. To identify potential targets for treating a multiple myeloma, a frequently incurable cancer, Kochenderfer and Kochenderfer analyze RNA sequencing data from the Cancer Cell Line Encyclopedia to find genes with high expression in multiple myeloma cells and low expression in normal tissues
Read More...The effect of common food preservatives on the heart rate of Daphnia magna
The authors test the effects of common food industry preservatives on the heart rate of the freshwater crustacean Daphnia magna.
Read More...Automated classification of nebulae using deep learning & machine learning for enhanced discovery
There are believed to be ~20,000 nebulae in the Milky Way Galaxy. However, humans have only cataloged ~1,800 of them even though we have gathered 1.3 million nebula images. Classification of nebulae is important as it helps scientists understand the chemical composition of a nebula which in turn helps them understand the material of the original star. Our research on nebulae classification aims to make the process of classifying new nebulae faster and more accurate using a hybrid of deep learning and machine learning techniques.
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