TNF signaling pathway upregulation as a potential pharmaceutical target for cocaine-addicted individuals
In this article, the authors investigate the RNA expression differences between groups of chronic cocaine abusers and drug-free subjects.
Read More...Gene expression profiling of MERS-CoV-London strain
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In this study, the authors identify transcripts and gene networks that are changed after infection with the Middle East Respiratory Syndrome-related coronavirus (MERS-CoV).
Read More...Upregulation of the Ribosomal Pathway as a Potential Blood-Based Genetic Biomarker for Comorbid Major Depressive Disorder (MDD) and PTSD
Major Depressive Disorder (MDD), and Post-Traumatic Stress Disorder (PTSD) are two of the fastest growing comorbid diseases in the world. Using publicly available datasets from the National Institute for Biotechnology Information (NCBI), Ravi and Lee conducted a differential gene expression analysis using 184 blood samples from either control individuals or individuals with comorbid MDD and PTSD. As a result, the authors identified 253 highly differentially-expressed genes, with enrichment for proteins in the gene ontology group 'Ribosomal Pathway'. These genes may be used as blood-based biomarkers for susceptibility to MDD or PTSD, and to tailor treatments within a personalized medicine regime.
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