Treatments inhibiting Notch signaling pathways have been explored by researchers as a new approach for the treatment of glioblastoma tumors, which is a fast-growing and aggressive brain tumor. Recently, retinoic acid (RA) therapy, which inhibits Notch signaling, has shown a promising effect on inhibiting glioblastoma progression. RA, which is a metabolite of vitamin A, is very important in embryonic cellular development, which includes the regulation of multiple developmental processes, such as brain neurogenesis. However, high doses of RA treatment caused many side effects such as headaches, nausea, redness around the injection site, or allergic reactions. Therefore, we hypothesized that a combination treatment of RA and siRNA targeting NOTCH1 (siNOTCH1), the essential gene that activates Notch signaling, would effectively inhibit brain cancer cell proliferation. The aim of the study was to determine whether inhibiting NOTCH1 would inhibit the growth of brain cancer cells by cell viability assay. We found that the combination treatment of siNOTCH1 and RA in low concentration effectively decreased the NOTCH1 expression level compared to the individual treatments. However, the combination treatment condition significantly decreased the number of live brain cancer cells only at a low concentration of RA. We anticipate that this novel combination treatment can provide a solution to the side effects of chemotherapy.

The authors compare neuroimaging datasets to identify potential new biomarkers for earlier detection of Alzheimer's disease.

The authors looked at how a 3D bioprinter could be used to model the blood brain barrier.

Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.

Here, seeking to better understand the control algorithms used in autonomous vehicles, the authors compared the Stanley and pure pursuit control algorithms along with a new version of each. Unexpectedly, they found that no control algorithm offered optimal performance, but rather resulted in tradeoffs between the various ideal results.

Complications of robotic-assisted surgery are on the rise, partly due to surgeons not receiving proper training. Al-Akash and Al-Akash hypothesized Nintendo JoyCon controls would improve surgical performance compared to the FDA-approved Da Vinci Surgical System with two user groups (doctor and gamer). Their results show that implementing a Nintendo JoyCon control system is associated with improved surgical performance and learning rate compared to the Da Vinci Surgical System.

Pandemics involve the high transmission of a disease that impacts global and local health and economic patterns. Epidemiological models help propose pandemic control strategies based on non-pharmaceutical interventions such as social distancing, curfews, and lockdowns, reducing the economic impact of these restrictions. In this research, we utilized an epidemiological Susceptible, Exposed, Infected, Recovered, Deceased (SEIRD) model – a compartmental model for virtually simulating a pandemic day by day.

Zebra mussels are an aquatic invasive species. They attach to essential industrial structures and harm the native ecosystem, costing millions of dollars each year to control. This study explored the effectiveness of two nontoxic materials (Sharklet & Netminder) in combating zebra mussel attachment.

Buildings, which are responsible for the majority of electricity consumption in cities like Dubai, are often exclusively reliant on electrical lighting even in the presence of daylight to meet the illumination requirements of the building. This inefficient use of lighting creates potential to further optimize the energy efficiency of buildings by complementing natural light with electrical lighting. Prior research has mostly used ballasts (variable resistors) to regulate the brightness of bulbs. There has been limited research pertaining to the use of pulse width modulation (PWM) and the use of ‘triodes for alternating current’ (TRIACs). PWM and TRIACs rapidly stop and restart the flow of current to the bulb thus saving energy whilst maintaining a constant illumination level of a space. We conducted experiments to investigate the feasibility of using TRIACs and PWM in regulating the brightness of bulbs. We also established the relationship between power and brightness within the experimental setups. Our results indicate that lighting systems can be regulated through these alternate methods and that there is potential to save up to 16% of energy used without affecting the overall lighting of a given space. Since most energy used in buildings is still produced through fossil fuels, energy savings from lighting systems could contribute towards a lower carbon footprint. Our study provides an innovative solution to conserve light energy in buildings during daytime.

The study discusses the relationship between bacterial species and the human gut microbiome, emphasizing the role of quorum sensing molecules in bacterial communication and its implications for health. Authors investigated the impact of bacterial supernatants from Escherichia coli (E. coli) on the growth of new E. coli and Enterobacter aerogenes (E. aerogenes) cultures.