Asthma affects over 334 million people worldwide and is triggered by inhalation of environmental stimuli. The authors of this study characterized the effect of exposure to common spoilage yeast, Pichia kidriavzevii on alveolar epithelial cells. A direct correlation between infection duration and asthmatic status of these cells was found, indicating the potential for this yeast to be an environmental stimulus of asthma and warranting further study.
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Risk factors contributing to Pennsylvania childhood asthma
Asthma is one of the most prevalent chronic conditions in the United States. But not all people experience asthma equally, with factors like healthcare access and environmental pollution impacting whether children are likely to be hospitalized for asthma's effects. Li, Li, and Ruffolo investigate what demographic and environmental factors are predictive of childhood asthma hospitalization rates across Pennsylvania.
Read More...Development of a Novel Treatment Strategy to Treat Parkinsonian Neurodegeneration by Targeting Both Lewy Body Aggregation and Dopaminergic Neuronal Degradation in a Drosophila melanogaster Model
In this article the authors address the complex and life quality-diminishing neurodegenerative disease known as Parkinson's. Although genetic and/or environmental factors contribute to the etiology of the disease, the diagnostic symptoms are the same. By genetically modifying fruit flies to exhibit symptoms of Parkinson's disease, they investigate whether drugs that inhibit mitochondrial calcium uptake or activate the lysosomal degradation of proteins could improve the symptoms of Parkinson's these flies exhibit. The authors report the most promising outcome to be that when both types of drugs were used together. Their data provides encouraging evidence to support further investigation of the utility of such drugs in the treatment of human Parkinson's patients.
Read More...Breaking the Ice: A Scientific Take on the Ice Melting Abilities of Household Salts
The use of salt to melt ice is a common and important practice to keep roadways safe during winter months. However, various subtypes of salt differ in their chemical and physical properties, as well as their environmental impact. In this study, the authors measure the effectiveness of different salts at disrupting ice structures and identify calcium chloride as the most effective.
Read More...Does technology help or hurt learning? Evidence from middle school and high school students
Here, recognizing the vastly different opinion held regarding device usage, the authors considered the effects of technology use on middle and high school students' learning effectiveness. Using an anonymous online survey they found partial support that device use at school increases learning effectiveness, but found strong support for a negative effect of technology use at home on learning effectiveness. Based on their findings they suggest that the efficacy of technology depends on environmental context along with other important factors that need consideration.
Read More...A new hybrid cold storage material
With low-temperature transportation being critical for the progress of research and medical services by preserving biological samples and vaccines, the optimization of cold storage materials is more critical now than ever. The exclusive use of dry ice has its limitations. Notably, it proves insufficient for cold storage during long-range transportation necessary for the delivery of specimens to rural areas. In this article, the authors have proposed a new means of cold storage through the combination of dry ice and ethanol. Upon thorough analysis, the authors have determined their new method as considerably better than the use of pure dry ice across many characteristics, including cold storage capacity, longevity of material, and financial and environmental feasibility.
Read More...Testing Epoxy Strength: The High Strength Claims of Selleys’s Araldite Epoxy Glues
Understanding the techniques used to improve the adhesion strength of the epoxy resin is important especially for consumer applications such as repairing car parts, bonding aluminum sheeting, and repairing furniture or applications within the aviation or civil industry. Selleys Araldite epoxy makes specific strength claims emphasizing that the load or weight that can be supported by the adhesive is 72 kg/cm2. Nguyen and Clarke aimed to test the strength claims of Selley’s Araldite Epoxy by gluing two steel adhesion surfaces: a steel tube and bracket. Results showed that there is a lack of consideration by Selleys for adhesion loss mechanisms and environmental factors when accounting for consumer use of the product leading to disputable claims.
Read More...Evaluating Biomarkers and Treatments for Acute Kidney Injury in a Zebrafish Model
Coronary Artery Disease (CAD) is the leading cause of death in the United States, and 81% of Acute Kidney Injury (AKI) patients in the renal fibrosis stage later develop CAD. In this study, Mathew and Joykutty aimed to create a cost-effective strategy to treat AKI and thus prevent CAD using a model of the zebrafish, Danio rerio. They first tested whether AKI is induced in Danio rerio upon exposure to environmental toxins, then evaluated nitrotyrosine as an early biomarker for toxin-induced AKI. Finally, they evaluated 4 treatments of renal fibrosis, the last stage of AKI, and found that the compound SB431542 was the most effective treatment (reduced fibrosis by 99.97%). Their approach to treating AKI patients, and potentially prevent CAD, is economically feasible for translation into the clinic in both developing and developed countries.
Read More...Predicting college retention rates from Google Street View images of campuses
Every year, around 40% of undergraduate students in the United States discontinue their studies, resulting in a loss of valuable education for students and a loss of money for colleges. Even so, colleges across the nation struggle to discover the underlying causes of these high dropout rates. In this paper, the authors discuss the use of machine learning to find correlations between the built environment factors and the retention rates of colleges. They hypothesized that one way for colleges to improve their retention rates could be to improve the physical characteristics of their campus to be more pleasing. The authors used image classification techniques to look at images of colleges and correlate certain features like colors, cars, and people to higher or lower retention rates. With three possible options of high, medium, and low retention rates, the probability that their models reached the right conclusion if they simply chose randomly was 33%. After finding that this 33%, or 0.33 mark, always fell outside of the 99% confidence intervals built around their models’ accuracies, the authors concluded that their machine learning techniques can be used to find correlations between certain environmental factors and retention rates.
Read More...Lactic acid bacteria protect the growth of Solanum lycopersicum from Sodium dodecyl sulfate
Sodium dodecyl sulfate (SDS), a detergent component, can harm plant growth when it contaminates soil and waterways. Authors explored the potential of lactic acid bacteria (LAB) to mitigate SDS-induced stress on plants.
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