The authors test the effects of the pesticide captan on the growth of gut microbiome bacteria including Bacillus coagulan and Escherichia coli.
Read More...Inhibitory effects of captan on growth of Escherichia coli and Bacillus coagulans
The authors test the effects of the pesticide captan on the growth of gut microbiome bacteria including Bacillus coagulan and Escherichia coli.
Read More...Quantitative NMR spectroscopy reveals solvent effects in the photochemical degradation of thymoquinone
Thymoquinone is a compound of great therapeutic potential and scientific interest. However, its clinical administration and synthetic modifications are greatly limited by its instability in the presence of light. This study employed quantitative 1H nuclear magnetic resonance (NMR) spectroscopy to identify the effect of solvation on the degradation of thymoquinone under ultraviolet light (UV). It found that the rate of degradation is highly solvent dependent occurs maximally in chloroform.
Read More...Quantitative definition of chemical synthetic pathway complexity of organic compounds
Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.
Read More...Household spices and minerals as alternative disinfectants for mobile phones
In this study, the authors investigate the disinfectant potential of many household spices and minerals. More specifically, they test whether these compounds can be used to disinfect mobile phones after daily use with the hope of identifying environmentally-friendly cleaning options.
Read More...Estimating the Young’s Modulus of spaghetti with a buckling experiment
The Young's Modulus of a structural material is a measure of its elasticity and is defined as the ratio of the tensile stress to tensile strain. This study aims to investigate the Young's Modulus of pasta with different diameters.
Read More...The effects of different modes of vocalization and food consumption on the level of droplet transmission of bacteria
Microbial agents reposnsible for respiratory infections are often carried in spittle, which means they can be easily transmitted. Here, the authors investigate how likely certain activities are to spread microbes carried in spittle. They also investigate whether eating certain types of food might reduce the spread of spittle-borne bacteria too.
Read More...Implementing machine learning algorithms on criminal databases to develop a criminal activity index
The authors look at using publicly available data and machine learning to see if they can develop a criminal activity index for counties within the state of California.
Read More...The effects of UV-C and ionizing radiation on the functions of Escherichia Coli
In this study, the authors send E. coli cultures to space via the Cubes in SpaceTM program to determine if ultraviolet C and ionizing radiation negatively affect bacterial growth.
Read More...Comparative screening of dose-dependent and strain-specific antimicrobial efficacy of berberine against a representative library of broad-spectrum antibiotics
We hypothesize that berberine has broad-spectrum antibacterial properties, along with potency that is comparable to current broad-spectrum antibiotics that are commercially available. Here, we screened berberine against four strains of bacteria and evaluated its antimicrobial activity against five broad-spectrum antibiotics from different classes to better quantify berberine’s antibacterial activity and compare its efficacy as an antibacterial agent to the broad-spectrum antibiotics. Our results indicated that berberine had strain-selective cytotoxic effects and was significantly less potent than most of the broad-spectrum antibiotics
Read More...Down-regulation of CD44 inhibits Wnt/β-catenin mediated cancer cell migration and invasion in gastric cancer
In this study, we aimed to characterize CD44-mediated regulation of the Wnt/β-catenin signaling pathway, which promotes cancer invasion and metastasis. We hypothesized that CD44 down-regulation will inhibit gastric cancer cell migration and invasion by leading to down-regulation of Wnt/β-catenin signaling. We found that CD44 up-regulation was significantly related to poor prognosis in gastric cancer patients. We demonstrated the CD44 down-regulation decreased β-catenin protein expression level. Our results suggest that CD44 down-regulation inhibits cell migration and invasion by down-regulating β-catenin expression level.
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