In this study the authors looked at the extract of Stephania tetrandra and its impact on symptoms related to obsessive compulsive disorder in fruit flies.
Read More...Administration of Stephania tetrandra to Drosophila melanogaster to create obsessive compulsive disorder model
In this study the authors looked at the extract of Stephania tetrandra and its impact on symptoms related to obsessive compulsive disorder in fruit flies.
Read More...Novel biaryl imines and amines as potential competitive inhibitors of dihydropteroate synthase
In this study, the authors design a series of new biaryl small molecules to target and block the binding pocket of the enzyme dihydropteroate synthase, which is important for prokaryotic biosynthesis of folic acid and could serve as better antimicrobial compounds.
Read More...Comparing Virulence of Three T4 Bacteriophage Strains on Ampicillin-Resistant and Sensitive E. coli Bacteria
In this study, the authors investigate an alternative way to kill bacteria other than the use of antibiotics, which is useful when considering antibiotic-resistance bacteria. They use bacteriophages, which are are viruses that can infect bacteria, and measure cell lysis. They make some important findings that these bacteriophage can lyse both antibiotic-resistant and non-resistant bacteria.
Read More...Honey Bee Pollen in Allergic Rhinitis Healing
The most common atopic disease of the upper respiratory tract is allergic rhinitis. It is defined as a chronic inflammatory condition of nasal mucosa due to the effects of one or more allergens and is usually a long-term problem. The purpose of our study was to test the efficiency of apitherapy in allergic rhinitis healing by the application of honey bee pollen. Apitherapy is a branch of alternative medicine that uses honey bee products. Honey bee pollen can act as an allergen and cause new allergy attacks for those who suffer from allergic rhinitis. Conversely, we hoped to prove that smaller ingestion of honey bee pollen on a daily basis would desensitize participants to pollen and thus reduce the severity of allergic rhinitis.
Read More...Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1
Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.
Read More...Cytotoxicity evaluation of Amaranthus extracts compared with AS20 on MCF-7 cancer cells
The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.
Read More...Cell cytotoxicity and pro-apoptosis on MCF-7 cells using polyherbal formulation, MAT20
The purpose of this study was to test the anti-cancer properties and pro-apoptotic effects of the polyherbal formulation MAT20 as a complementary treatment. Moringa oleifera (Moringa), Phyllanthus emblica (Amla) and Ocimum sanctum (Tulsi), these 3 herbs were used to formulate MAT20, which contain phytochemicals that are known to display anti-cancer properties. In this study, we hypothesized that MCF-7 breast cancer cells treated with MAT20 would show increased cytotoxicity compared to its individual plant extracts.
Read More...One-step photochemical crosslinking of native proteins is feasible in tyrosine-rich bovine serum albumin
In this study, the authors develop a new hydrogel using photochemical crosslinking with bovine serum albumin and methylene blue. They find that this new hydrogel has some useful applications!
Read More...Luteolin's positive inhibition of melanoma cell lines.
Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a flavonoid that occurs in fruits, vegetables, and herbs. Research suggests that luteolin is effective against various forms of cancer by triggering apoptosis pathways. This experiment analyzes the effects of luteolin on the cell viability of malignant melanoma cells using an in vitro experiment to research alternative melanoma treatments and hopefully to help further cancer research as a whole.
Read More...Utilizing sorbitol to improve properties of cellulose-based biodegradable hydrogels
Hydrogels are commonly used in medicine, pharmaceuticals, and agriculture. Hydrogels absorb water by swelling and re-release this water by diffusion. This study sought to synthesize a biodegradable, cellulose-based hydrogel that is more effective at absorbing and re-releasing water than those produced by current methods. We tested the compressive strength of both the dry and swollen gels and the tensile strength of the swollen gels to elucidate the gel structure.
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