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Validating DTAPs with large language models: A novel approach to drug repurposing

Curtis et al. | Mar 02, 2025

Validating DTAPs with large language models: A novel approach to drug repurposing
Image credit: Growtika

Here, the authors investigated the integration of large language models (LLMs) with drug target affinity predictors (DTAPs) to improve drug repurposing, demonstrating a significant increase in prediction accuracy, particularly with GPT-4, for psychotropic drugs and the sigma-1 receptor. This novel approach offers to potentially accelerate and reduce the cost of drug discovery by efficiently identifying new therapeutic uses for existing drugs.

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Country-level relationship of OTC medicine consumption and frequency of GP consultation

Hirai et al. | Dec 09, 2024

Country-level relationship of OTC medicine consumption and frequency of GP consultation

The discussion surrounding self-medication with non-prescription medicines has gained significance in healthcare and public health, particularly given the global increase in consumption of non-prescription drugs. This study aimed to examine the association between the frequency of general practitioner (GP) consultations and the proportion of economic resources spent on OTC medicine.

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Modeling the heart’s reaction to narrow blood vessels

Athulathmudali et al. | May 22, 2023

Modeling the heart’s reaction to narrow blood vessels

Cardiovascular diseases are the largest cause of death globally, making it a critical area of focus. The circulatory system is required to make the heart function. One component of this system is blood vessels, which is the focus of our study. Our work aims to demonstrate the numeric relationship between a blood vessel's diameter and the number of pumps needed to transport blood.

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Behavioral Longevity: The Impact of Smoking, Alcohol Consumption, and Obesity on Life Expectancy

Han et al. | Oct 03, 2019

Behavioral Longevity: The Impact of Smoking, Alcohol Consumption, and Obesity on Life Expectancy

In this article, the authors look into what is already known about the factor affecting longevity and determine the importance of behavioral factors including alcohol consumption, smoking, and obesity on longevity. The authors quantify data from over 150 countries and, interestingly, find that the impact each factor has on longevity is at least in part dependent on the country's economic development status. Overall, they conclude that an average person’s life expectancy can increase by more than 3 years if smoking and alcohol consumption is reduced by a half and weight is decreased by 10%.

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Using Artificial Intelligence to Forecast Continuous Glucose Monitor(CGM) readings for Type One Diabetes

Jalla et al. | Aug 07, 2024

Using Artificial Intelligence to Forecast Continuous Glucose Monitor(CGM) readings for Type One Diabetes
Image credit: The authors

People with Type One diabetes often rely on Continuous Blood Glucose Monitors (CGMs) to track their blood glucose and manage their condition. Researchers are now working to help people with Type One diabetes more easily monitor their health by developing models that will future blood glucose levels based on CGM readings. Jalla and Ghanta tackle this issue by exploring the use of AI models to forecast blood glucose levels with CGM data.

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