In this study, the authors investigate whether phototaxis and odortaxis in Drosophila melanogaster occurs through linear summation of cues including light and attractive odorants.
Read More...Linear and non-linear summation of responses to visual and olfactory cues in male Drosophila melanogaster
In this study, the authors investigate whether phototaxis and odortaxis in Drosophila melanogaster occurs through linear summation of cues including light and attractive odorants.
Read More...Using explainable artificial intelligence to identify patient-specific breast cancer subtypes
Breast cancer is the most common cancer in women, with approximately 300,000 diagnosed with breast cancer in 2023. It ranks second in cancer-related deaths for women, after lung cancer with nearly 50,000 deaths. Scientists have identified important genetic mutations in genes like BRCA1 and BRCA2 that lead to the development of breast cancer, but previous studies were limited as they focused on specific populations. To overcome limitations, diverse populations and powerful statistical methods like genome-wide association studies and whole-genome sequencing are needed. Explainable artificial intelligence (XAI) can be used in oncology and breast cancer research to overcome these limitations of specificity as it can analyze datasets of diagnosed patients by providing interpretable explanations for identified patterns and predictions. This project aims to achieve technological and medicinal goals by using advanced algorithms to identify breast cancer subtypes for faster diagnoses. Multiple methods were utilized to develop an efficient algorithm. We hypothesized that an XAI approach would be best as it can assign scores to genes, specifically with a 90% success rate. To test that, we ran multiple trials utilizing XAI methods through the identification of class-specific and patient-specific key genes. We found that the study demonstrated a pipeline that combines multiple XAI techniques to identify potential biomarker genes for breast cancer with a 95% success rate.
Read More...Taft linear free-energy relationships in the biocatalytic hydrolysis of sterically hindered nitrophenyl ester substrates
This study applies Taft linear free-energy relationships to study kinetic trends in the enzymatic hydrolysis of sterically hindered substrates.
Read More...Identification of a Free Radical Scavenger as an Additive for Lung Transplant Preservation Solution to Inhibit Coagulative Necrosis and Extend Organ Preservation
During transfer of organs from a donor to a patient, the organs deteriorate in part due to damage by free radicals. Application of antioxidant solutions could extend organ preservation times. The authors found that vitamin E and butylated hydroxytoluene seemed to be most effective in arresting cell damage of a bovine lung.
Read More...Bacterial Load Consistency Among Three Independent Water Distribution Systems
Clean drinking water is an essential component to maintaining public health. The authors of this study tested the bacterial load of water from three different disinfection and filtration systems in order to determine which system might be superior.
Read More...Comparison of three large language models as middle school math tutoring assistants
Middle school math forms the basis for advanced mathematical courses leading up to the university level. Large language models (LLMs) have the potential to power next-generation educational technologies, acting as digital tutors to students. The main objective of this study was to determine whether LLMs like ChatGPT, Bard, and Llama 2 can serve as reliable middle school math tutoring assistants on three tutoring tasks: hint generation, comprehensive solution, and exercise creation.
Read More...Hammett linear free-energy relationships in the biocatalytic hydrolysis of para-substituted nitrophenyl benzoate esters
As the world moves towards more eco-friendly methods for chemical synthesis, there's a strong interest in employing enzymes in chemical synthetic processes. Here, the authors explore how the activity of enzymes such as trypsin, lipase and nattokinase is affected by the electronic effects of the substrate they are acting on.
Read More...Estimating the elastic modulus and bending stiffness of steel ruler with crack using three-point bending test
In this study the authors look at elastic modulus and stiffness of steel rules with vary lengths of cracks. They found that cracks decreased the overall elastic modulus and bending stiffness of the ruler. This work has applications to structural engineering and the design of items such as airplanes and bridges.
Read More...Reducing levels of C-Reactive Protein: An eight-week, open-label clinical trial of three oral supplements
In this study, the effects of vitamin C, ginger, or curcumin supplements on C-reactive protein levels in healthy participants are determined in an eight-week open-label trial.
Read More...Comparing Virulence of Three T4 Bacteriophage Strains on Ampicillin-Resistant and Sensitive E. coli Bacteria
In this study, the authors investigate an alternative way to kill bacteria other than the use of antibiotics, which is useful when considering antibiotic-resistance bacteria. They use bacteriophages, which are are viruses that can infect bacteria, and measure cell lysis. They make some important findings that these bacteriophage can lyse both antibiotic-resistant and non-resistant bacteria.
Read More...Search articles by title, author name, or tags