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Cocktail therapy to inhibit multispecies biofilm in cystic fibrosis patients

Bhat et al. | Sep 22, 2022

Cocktail therapy to inhibit multispecies biofilm in cystic fibrosis patients

Here, recognizing the important role of bacterial biofilms in many life-threatening chronic infections, the authors investigated the effectiveness of a combination treatment on biofilms composed of up to three different common species within the lungs of cystic fibrosis patients with computational analysis. They found that a triple cocktail therapy targeting three different signaling pathways has significant potential as both a treatment and prophylaxis.

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The role of xpa-1 and him-1 in UV protection of Caenorhabditis elegans

Tung et al. | Feb 25, 2022

The role of <em>xpa-1</em> and <em>him-1</em> in UV protection of <em>Caenorhabditis elegans</em>

Caenorhabditis elegans xpa-1 and him-1 are orthologs of human XPA and human SMC1A, respectively. Mutations in the XPA are correlated with Xeroderma pigmentosum, a condition that induces hypersensitivity to ultraviolet (UV) radiation. Alternatively, SMC1A mutations may lead to Cornelia de Lange Syndrome, a multi-organ disorder that makes patients more sensitive to UVinduced DNA damage. Both C. elegans genes have been found to be involved in protection against UV radiation, but their combined effects have not been tested when they are both knocked down. The authors hypothesized that because these genes are involved in separate pathways, the simultaneous knockdown of both of these genes using RNA interference (RNAi) in C. elegans will cause them to become more sensitive to UV radiation than either of them knocked down individually. UV protection was measured via the percent survival of C. elegans post 365 nm and 5.4x10-19 joules of UV radiation. The double xpa-1/him-1 RNAi knockdown showed a significantly reduced percent survival after 15 and 30 minutes of UV radiation relative to wild-type and xpa-1 and him-1 single knockdowns. These measurements were consistent with their hypothesis and demonstrated that xpa-1 and him-1 genes play distinct roles in resistance against UV stress in C. elegans. This result raises the possibility that the xpa-1/him-1 double knockdown could be useful as an animal model for studying the human disease Xeroderma pigmentosum and Cornelia de Lange Syndrome.

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Analyzing the effects of multiple adhesives on elastic collisions and energy loss in a Newton’s Cradle

Isham et al. | Feb 02, 2024

Analyzing the effects of multiple adhesives on elastic collisions and energy loss in a Newton’s Cradle

The energy conservation in a system of objects in collision depends on the elasticity of the objects and environmental factors such as air resistance. One system that relies heavily on elasticity is the Newton’s Cradle. We aimed to determine the extent to which these adhesives serve to mitigate or worsen the chaotic movements and elastic collisions.

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Testing Different Polymers and Boron Nitride Nanotube Properties in Fabrication of Ion-selective Membranes

Yi et al. | Sep 28, 2020

Testing Different Polymers and Boron Nitride Nanotube Properties in Fabrication of Ion-selective Membranes

One largely untapped source of clean energy is the use of osmotic gradients where freshwater and saltwater are mixed, for example at estuaries. To harness such energy, charge-selective membranes are needed to separate the anions and cations in saltwater, establishing an electric potential like a battery. The objective of this study was twofold: to investigate the creation of the polymer matrix and test the properties of boron nitride nanotubes, as both are essential in the creation of an ion-selective membrane. Out of three polymer samples tested in this study, the mixture known as Soltech 704 showed the best resistance to etching, as well as the highest UV cure rate.

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Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs

Sun et al. | Nov 17, 2020

Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs

In this study, the authors investigate the antimicrobial effects of berberine and berberine analogs. Berberine is extracted from plants and is a naturally occurring alkaloid, and is also excited photochemically. Using three different assays, the authors tested whether these compounds would inhibit bacterial growth. They found that these compounds were antibacterial and even more so when used with photoirradiation. This study has important antibacterial implications.

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Impact of light intensity and electrolyte volume on performance of photo-electrochemical (PEC) solar cell

Patel et al. | Mar 14, 2022

Impact of light intensity and electrolyte volume on performance of photo-electrochemical (PEC) solar cell

Here, seeking to develop more efficient solar cells, the authors investigated photo-electrochemical (PEC) solar cells, specifically molybdenum diselenide (MoSe2) based on its high resistance to corrosion. They found that the percentage efficiency of these PEC solar cells was proportional to light intensity–0.9 and that performance was positively influenced by increasing the electrolyte volume. They suggest that studies such as these can lead to new insight into reaction-based solar cells.

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How are genetically modified foods discussed on TikTok? An analysis of #GMOFOODS

Basch et al. | Nov 20, 2023

How are genetically modified foods discussed on TikTok? An analysis of #GMOFOODS
Image credit: Camilo Jimenez

Here, the authors investigated engagement with #GMOFOODS, a hashtag on TikTok. They hypothesized that content focused on the negative effects of genetically modified organisms would receive more interaction driven by consumers. They found that the most common cateogry focused on the disadvantages of GMOs related to nutrition and health with the number of views determining if the video would be provided to users.

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