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The authors investigate whether human blood cancers carrying mutations in DNA repair genes possess increased sensitivity to common chemotherapy drugs cisplatin or gemcitabine.

Here recognizing the potential for pollution to impact the ecosystems of local waterways, the authors investigated the growth of tiger lilies, which are invasive to the Potomac River, in relation to the level of pollution. The authors report that increasing levels of pollution led to increased growth of the invasive species based on their study.

Using the European Space Agency’s Gaia dataset, the authors analyzed the relationship between white dwarfs’ magnitudes and proper motions. They hypothesized that older white dwarf stars may have different velocities than younger ones, possibly that stars slow down as they age. They found that the white dwarfs in the dataset were substantially redder and higher magnitude (traits traditionally associated with older stars) as compared to their non-fast counterparts.

In this study, the authors address potential reasons why employees may voluntarily resign. This is in response to the currently observed economic trend The Great Resignation. Through analysis of federal and local government data along with survey results from Fairfax County, they concluded that adding additional benefits will help companies retain talented empolyees.

Here, the authors explored how the sale and use of electric vehicles could reduce emissions from the transport industry in Canada. By fitting the sale of total of electric vehicles with an exponential model, the authors predicted the number of electric vehicle sales through 2030 and related that to the average emission for such vehicles. Ultimately, they found that the sale and use of electric vehicles alone would likely not meet the 45% reduction in emissions from the transport industry suggested by the Canadian government

In this study, the authors determine which house model is most resistant to high winds by building smaller prototypes that could be tested with a handheld source of wind.

In this study, the authors hypothesized that closed-circuit television images could be stored with improved resolution by using enhanced deep residual (EDSR) networks.

Here, seeking to better understand the control algorithms used in autonomous vehicles, the authors compared the Stanley and pure pursuit control algorithms along with a new version of each. Unexpectedly, they found that no control algorithm offered optimal performance, but rather resulted in tradeoffs between the various ideal results.

In this study, the authors measure the relationship between the Gini coefficient, a common measure of income inequality, and Black and White maternal mortality rates by state and year.

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.