Browse Articles

In this article, the authors investigate the RNA expression differences between groups of chronic cocaine abusers and drug-free subjects.

Pancreatic cancer is one of the deadliest cancers, with a 10% 5-year survival rate. The authors studied various dosages of TPEN and zinc in combination with Chloroquine and Gemcitabine as treatments to reduce cell proliferation. Results showed that when combined with Chloroquine and Gemcitabine, zinc and TPEN both significantly lowered cell proliferation compared to Gemcitabine, suggesting a synergistic effect that resulted in a more cytotoxic treatment. Further research and clinical trials on this topic are needed to determine whether this could be a viable treatment for pancreatic cancer.

Free radical chain reactions result when atoms containing unpaired electrons bind with biomolecules and alter their biological functions, contributing to the progression of diseases such as atherosclerosis, cancer, and diabetes. Antioxidants, such as vitamin E and sulforaphane, are effective neutralizers of free radicals and prevent cellular damage. This present study is conducted to determine the relative effectiveness of sulforaphane against free radicals generated by hydrogen peroxide (H2O2) compared with the known antioxidant vitamin E.

Omega-3 fatty acid derived lipid mediators have been implicated in resolving inflammation, and wound healing. Authors measured the impact of supplementation with lipid mediator Resolvin D1 and its precursor 17-HDHA on planaria regeneration. Planaria not only synthesize RvD1 from 17-DHA, but both RvD1 and 17-DHA enhanced regeneration.

Current osteosarcoma (OS) treatments rely on surgery and chemotherapy, but drug resistance remains a major challenge that lowers patient survival rates. Ferroptosis, a form of regulated cell death, has shown promise in cancer therapy but is not well understood in OS. This study explores the use of Ferroptosis in OS.

The authors looked at the primary structure of lignin peroxidase in an attempt to identify mutations that would improve both the stability and solubility of the peroxidase protein. The goal is to engineer peroxidase enzymes that are stable to help break down polymers, such as PVC, into monomers that can be reused instead of going to landfills.

This article explores the largely unstudied impact of noise pollution on plant life. By exposing Arabidopsis thaliana seedlings to urban traffic noise, the study found a significant increase in seedling growth, alongside substantial changes in gene expression. This research reveals critical insights into how noise pollution affects plant physiology and contributes to a broader understanding of its ecological impacts, helping to guide future efforts in ecosystem conservation.

The study discusses the relationship between bacterial species and the human gut microbiome, emphasizing the role of quorum sensing molecules in bacterial communication and its implications for health. Authors investigated the impact of bacterial supernatants from Escherichia coli (E. coli) on the growth of new E. coli and Enterobacter aerogenes (E. aerogenes) cultures.

The authors test potential anti-inflammatory and pro-apoptotic effects of a polyherbal extract formulation on cultured breast cancer cells.

Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.