The authors use machine learning on MRI images of brain tissue to predict tumor onset as an avenue for early detection of brain cancer.
Read More...A comparative analysis of machine learning approaches to predict brain tumors using MRI
The authors use machine learning on MRI images of brain tissue to predict tumor onset as an avenue for early detection of brain cancer.
Read More...Risk assessment modeling for childhood stunting using automated machine learning and demographic analysis
Over the last few decades, childhood stunting has persisted as a major global challenge. This study hypothesized that TPTO (Tree-based Pipeline Optimization Tool), an AutoML (automated machine learning) tool, would outperform all pre-existing machine learning models and reveal the positive impact of economic prosperity, strong familial traits, and resource attainability on reducing stunting risk. Feature correlation plots revealed that maternal height, wealth indicators, and parental education were universally important features for determining stunting outcomes approximately two years after birth. These results help inform future research by highlighting how demographic, familial, and socio-economic conditions influence stunting and providing medical professionals with a deployable risk assessment tool for predicting childhood stunting.
Read More...Validating DTAPs with large language models: A novel approach to drug repurposing
Here, the authors investigated the integration of large language models (LLMs) with drug target affinity predictors (DTAPs) to improve drug repurposing, demonstrating a significant increase in prediction accuracy, particularly with GPT-4, for psychotropic drugs and the sigma-1 receptor. This novel approach offers to potentially accelerate and reduce the cost of drug discovery by efficiently identifying new therapeutic uses for existing drugs.
Read More...Quantifying natural recovery of dopamine deficits induced by chronic stress
Here the authors investigated the natural recovery of stress-induced dopamine-related gene deficits in C. elegans by measuring the expression of cat-2 (dopamine biosynthesis) and sod-2 (oxidative stress) following exposure to starvation or hydrocortisone. They found that the reversibility of sod-2 and the expression of cat-2 were highly dependent on the type and severity of the stressor, suggesting that the body's natural ability to recover from dopamine dysfunction has biological limitations.
Read More...Evaluating the effectiveness of synthetic training data for day-ahead wind speed prediction in the Great Lakes
The authors looked at the feasibility to predict wind speeds that will have less reliance on using historical data.
Read More...Evaluation of in vitro anti-inflammatory effect of PLAY® on UC-MSCs: A COX-2 expression study
The authors seek to accelerate wound healing by reducing inflammation with a cocktail containing growth factors and bioactive modulators.
Read More...Analysis of antibiotic resistance genes in publicly accessible Staphylococcus aureus genomes
The authors looked at how the presence of difference antibiotic resistance genes would influence antibiotic resistance in Staphylococcus aureus.
Read More...In vitro dissolution and in vivo response of pseudoephedrine dosage forms
The authors looked at how pharmacokinetics changed depending on the use of an in vitro or an in vivo model.
Read More...Enhanced soil fertility through seaweed-derived biochar: A comparative analysis with commercial fertilizers
The study explored converting Gracilaria seaweed waste—known for releasing toxic hydrogen sulfide when decomposed—into biochar as a sustainable solution for waste management and soil improvement.
Read More...Training neural networks on text data to model human emotional understanding
The authors train a neural network to detect text-based emotions including joy, sadness, anger, fear, love, and surprise.
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