The authors used RNA-seq datasets to assess the effect of CDK7 inhibition on transcriptional pathways in castration-resistant prostate cancer cells.
Read More...CDK7 inhibition disrupts androgen signaling and induces metabolic rewiring in prostate cancer cells
The authors used RNA-seq datasets to assess the effect of CDK7 inhibition on transcriptional pathways in castration-resistant prostate cancer cells.
Read More...Bacteriophage TLS sensitizes Escherichia coli to antibiotics
Antibiotic resistance is a growing global health threat, and one strategy to combat it is using bacteriophages to enhance the effectiveness of existing antibiotics. This study tested whether targeting the TolC protein in E. coli with the TLS bacteriophage would increase bacterial sensitivity to antibiotics.
Read More...Novel anticancer effects of melatonin and berberine via signaling pathways in colorectal cancer and lymphoma
The authors looked at the ability of berberine in combination with melatonin to have anticancer effects when tested in an in vitro cell model.
Read More...Modeling the moving sofas in circular hallways using geometric methods
Investigation of the largest rigid shape that can be moved through a circular hallway of unit width with an arbitrary turn angle
Read More...Visualizing black holes and wormholes through raytracing
The authors visualized black holes and wormholes using code and ray-tracing programs.
Read More...The effect of calcium on mealworm iron metabolism
The authors looked at the impact of calcium on iron absorption in mealworms, hypothesizing that calcium would inhibit iron absorption.
Read More...Initiating astrocyte to neuron transdifferentiation via miR-124a: implications in neurodegenerative disease
The authors looked at whether they could induce the formation of new neurons from astrocytes via the upregulation of a microRNA (miR-124a). They found that upregulation of miR-124a started transdifferentiation of neurons, but was not enough to lead to full conversion of astrocytes to neurons.
Read More...SeniorConnect: A low-cost, app-based real-time alert system to connect seniors with their caregivers
The authors design and test an easy-to-use and cost-effective mobile app-based alert system to help senior citizens rapidly communicate with caregivers in emergencies or when in need of assistance.
Read More...Citrate and lactate drive glioblastoma progression via activation of tumor-associated macrophages
The authors looked at the impact of citrate and lactate on glioblastoma progression. Their results provide important insights for future immunotherapies aimed at treating glioblastoma.
Read More...Effect of environmental factors on bacterial flora of normal human skin
The authors looked how different working conditions impacted the microbiome of the human skin.
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