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The characterization of quorum sensing trajectories of Vibrio fischeri using longitudinal data analytics

Abdel-Azim et al. | Dec 16, 2023

The characterization of quorum sensing trajectories of <i>Vibrio fischeri</i> using longitudinal data analytics

Quorum sensing (QS) is the process in which bacteria recognize and respond to the surrounding cell density, and it can be inhibited by certain antimicrobial substances. This study showed that illumination intensity data is insufficient for evaluating QS activity without proper statistical modeling. It concluded that modeling illumination intensity through time provides a more accurate evaluation of QS activity than conventional cross-sectional analysis.

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Integrated expression, mutation, and survival analysis of 17 key genes in breast cancer using TCGA-BRCA data

Wang et al. | Aug 06, 2026

Integrated expression, mutation, and survival analysis of 17 key genes in breast cancer using TCGA-BRCA data

This study combines gene expression, mutation profiling, and survival analysis of 17 clinically important genes in breast cancer, utilizing the TCGA-BRCA dataset. Our results show that there are different patterns of oncogene upregulation, different levels of tumor suppressor activity, and complicated survival associations. TP53 was the most frequently mutated gene in this cohort. The results underscore the significance of multidimensional genomic analyses for a comprehensive understanding of breast cancer biology and its therapeutic ramifications.

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Color photometry and light curve modeling of apparent transient 2023jri

Favretto et al. | Aug 13, 2024

Color photometry and light curve modeling of apparent transient 2023jri

Observing transients like supernovae, which have short-lived brightness variations, helps astronomers understand cosmic phenomena. This study analyzed transient 2023jri, hypothesizing it was a Type IIb supernova. By collecting and analyzing data over four weeks, including light and color curves, they confirmed its classification and provided additional insights into this less-studied supernova type.

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Development of a novel machine learning platform to identify structural trends among NNRTI HIV-1 reverse transcriptase inhibitors

Ashok et al. | Jun 24, 2022

Development of a novel machine learning platform to identify structural trends among NNRTI HIV-1 reverse transcriptase inhibitors

With advancements in machine learning a large data scale, high throughput virtual screening has become a more attractive method for screening drug candidates. This study compared the accuracy of molecular descriptors from two cheminformatics Mordred and PaDEL, software libraries, in characterizing the chemo-structural composition of 53 compounds from the non-nucleoside reverse transcriptase inhibitors (NNRTI) class. The classification model built with the filtered set of descriptors from Mordred was superior to the model using PaDEL descriptors. This approach can accelerate the identification of hit compounds and improve the efficiency of the drug discovery pipeline.

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Exploring the Factors that Drive Coffee Ratings

Agarwal et al. | May 19, 2025

Exploring the Factors that Drive Coffee Ratings

This study explores the factors that influence coffee quality ratings using data from the Coffee Quality Institute. Through a regression model based on gradient descent, the authors aimed to predict coffee ratings (total cup points) and hypothesized that sweetness and the coffee producer would be the most influential factors.

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Racial disparities in school discipline in Collier County, Florida

Khan et al. | Jun 21, 2024

Racial disparities in school discipline in Collier County, Florida
Image credit: Ivan Aleksic

Here, the authorized analyzed data from the Florida Department of Education Office of Safe Schools regarding disciplinary outcomes in Collier County public schools. They reported that Black Students were more likely to receive both in-school and out-of-school suspensions than White students, which they concluded suggests racial inequities in school discipline that requires addressing as a society.

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A novel deep learning model for visibility correction of environmental factors in autonomous vehicles

Dey et al. | Oct 31, 2022

A novel deep learning model for visibility correction of environmental factors in autonomous vehicles

Intelligent vehicles utilize a combination of video-enabled object detection and radar data to traverse safely through surrounding environments. However, since the most momentary missteps in these systems can cause devastating collisions, the margin of error in the software for these systems is small. In this paper, we hypothesized that a novel object detection system that improves detection accuracy and speed of detection during adverse weather conditions would outperform industry alternatives in an average comparison.

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