In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.

In our modern age, the burgeoning use of radios and radars has resulted in competition for electromagnetic spectrum resources. With recent research highlighting solutions to radio and radar mutual interference, there is a desperate need for a cost-effective configuration that permits a radar-radio joint system. In this study, the authors have set out to determine the feasibility of using single-tone continuous-wave radars in a radar-joint system. With this system, they aim to facilitate cost-effective near-field target detection by way of the popularized 2.4-GHz industrial, scientific, and medical (ISM) band.

To best identify tuberculosis and pneumonia diagnoses in chest x-rays, the authors compare different deep learning convolution neural networks.

The authors looked at the ability of machine learning algorithms to interpret language given their increasing use in moderating content on social media. Using an explainable model they were able to achieve 81% accuracy in detecting fake vs. real news based on language of posts alone.

In this manuscript the authors looked at current vaccine strategies against different strains of influenza. Looking at several factors they found that influenza strain as well as vaccinated age group, among other factors, impact vaccine effectiveness.

Optical reporters like tetrazolium dyes, exemplified by 5-diphenyl tetrazolium bromide (MTT), are effective tools for quantifying cellular responses under experimental conditions. These dyes assess cell viability by producing brightly-colored formazan dyes when reduced inside active cells. However, certain small molecules, including reducing agents like ascorbic acid, cysteine, and glutathione (GSH), can interfere with MTT assays, potentially compromising accuracy.

The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.

In this study, the authors use high-throughput virtual screening to design and evaluate a set of non-nucleoside reverse transcriptase inhibitors for binding affinity to the protein reverse transcriptase. These studies have important applications toward HIV therapies.

The authors identify disinfectant-resistant bacterial strains of infection-causing bacteria from samples collected at a hospital setting.

Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.