Thymoquinone is a compound of great therapeutic potential and scientific interest. However, its clinical administration and synthetic modifications are greatly limited by its instability in the presence of light. This study employed quantitative 1H nuclear magnetic resonance (NMR) spectroscopy to identify the effect of solvation on the degradation of thymoquinone under ultraviolet light (UV). It found that the rate of degradation is highly solvent dependent occurs maximally in chloroform.
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Synthesis of a novel CCR1 antagonist for treatment of glioblastoma
Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.
Read More...Understanding the Mechanism of Star-Block Copolymers as Nanoreactors for Synthesis of Well-Defined Silver Nanoparticles
Here, the authors characterize how silver ions nucleate a star-block copolymer to generate nano-sized silver particles.
Read More...Deuterated solvent effects in the kinetics and thermodynamics of keto-enol tautomerization of ETFAA
In this study, the authors determined whether tautomerization dynamics in protic and aprotic solvents displayed differences in reaction rates and in the proportion of the keto and enol tautomers present.
Read More...Generation of a magnetic field on Mars
The authors propose and test a method that would allow for the generation of a magnetic field on Mars sufficient to support future colonization.
Read More...Simulation of cosmic rays in the presence of a magnetic field
In this study the authors looked the trajectories of cosmic rays moving through a dipole field. They found that the trajectories of cosmic rays are determined by a particle's energy and interaction with Earth's B field.
Read More...Diamagnetic Solutions Show a Significant Reduction in Flow Rate When Exposed to a Magnetic Field Greater Than or Equal to 0.7 Tesla
There are complex interactions between water and outside forces such as magnetic fields. This study aims to examine the effects of magnetic forces on the flow rate of water. The alteration of flow rate by magnets could have exciting applications in many fields.
Read More...A novel calibration algorithm and its effects on heading measurement accuracy of a low-cost magnetometer
Digital compasses are essential in technology that we use in our everyday lives: phones, vehicles, and more. Li and Liu address the accuracy of these devices by presenting a new algorithm for accurately calibrating low-cost magnetometers.
Read More...Floor level estimation using MEMS pressure sensors
The authors propose a method to help first responders find the location of a person within a high-rise building in densely populated areas.
Read More...The Effects of Atmospheric Attenuation on Cosmic Ray Muons: How is Surface Level Cosmic Ray Muon Flux Affected by Atmospheric Attenuation?
Cosmic rays are high-energy astronomical particles originating from various sources across the universe. Here, The authors sought to understand how surface-level cosmic-ray muon flux is affected by atmospheric attenuation by measuring the variation in relative muon-flux rate relative to zenith angle, testing the hypothesis that muons follow an exponential attenuation model. The attenuation model predicts an attenuation length of 6.3 km. This result implies that only a maximum of 24% of muons can reach the Earth’s surface, due to both decay and atmospheric interactions.
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