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The Clinical Accuracy of Non-Invasive Glucose Monitoring for ex vivo Artificial Pancreas

Levy et al. | Jul 10, 2016

The Clinical Accuracy of Non-Invasive Glucose Monitoring for <i>ex vivo</i> Artificial Pancreas

Diabetes is a serious worldwide epidemic that affects a growing portion of the population. While the most common method for testing blood glucose levels involves finger pricking, it is painful and inconvenient for patients. The authors test a non-invasive method to measure glucose levels from diabetic patients, and investigate whether the method is clinically accurate and universally applicable.

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Comparing the Effectiveness of Popular Treatments for Swelling and Scarring

Benavides et al. | Jul 08, 2020

Comparing the Effectiveness of Popular Treatments for Swelling and Scarring

Numerous specialty treatments claim to reduce swelling and scarring; however, it is unknown if these treatments are more effective than less expensive treatments. In an attempt to determine if one outperforms the other, treatments were applied to the same subject following bilateral orthopedic foot surgery. No difference was found the specialty treatments compared to more cost-effective treatments.

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The Effect of Concentration on the Pressure of a Sodium Chloride Solution Inside Dialysis Tubing

Dye et al. | Nov 13, 2018

The Effect of Concentration on the Pressure of a Sodium Chloride Solution Inside Dialysis Tubing

In this study, the authors investigate the effects of sodium levels on blood pressure, one of the most common medical problems worldwide. They used a simulated blood vessel constructed from dialysis tubing to carefully analyze pressure changes resulting from various levels of sodium in the external solution. They found that when the sodium concentration in the simulated blood vessel was higher than the external fluid, internal pressure increased, while the reverse was true when the sodium concentration was lower than in the surrounding environment. These results highlight the potential for sodium concentration to have a significant effect on blood pressure in humans by affecting the rate of osmosis across the boundaries of actual blood vessels.

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Synergistic Effects of Metformin and Captopril on C. elegans

Kadıoğlu et al. | Jul 10, 2018

Synergistic Effects of Metformin and Captopril on <em>C. elegans</em>

Kadıoğlu and Oğuzalp study the synergistic effects of Metformin and Captopril, two commonly prescribed drugs for type 2 diabetes and hypertension, respectively. Using C. elegans nematodes as a model system, the authors find that the nematodes decreased in average body length when exposed to Metformin or Captopril individually, but grew 11% in body length when both drugs were used together. Because C. elegans body size is regulated in part by the TGF-β signaling pathway, the authors suggest that synergistic effects of these two drugs may be modulating TGF-β activity, a previously uncharacterized phenomenon.

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The Development and Maximization of a Novel Photosynthetic Microbial Fuel Cell Using Rhodospirillum rubrum

Gomez et al. | Mar 02, 2014

The Development and Maximization of a Novel Photosynthetic Microbial Fuel Cell Using <em>Rhodospirillum rubrum</em>

Microbial fuel cells (MFCs) are bio-electrochemical systems that utilize bacteria and are promising forms of alternative energy. Similar to chemical fuel cells, MFCs employ both an anode (accepts electrons) and a cathode (donates electrons), but in these devices the live bacteria donate the electrons necessary for current. In this study, the authors assess the functionality of a photosynthetic MFC that utilizes a purple non-sulfur bacterium. The MFC prototype they constructed was found to function over a range of environmental conditions, suggesting its potential use in industrial models.

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A new therapy against MDR bacteria by in silico virtual screening of Pseudomonas aeruginosa LpxC inhibitors

Liu et al. | Apr 27, 2022

A new therapy against MDR bacteria by <em>in silico</em> virtual screening of <em>Pseudomonas aeruginosa</em> LpxC inhibitors

Here, seeking to address the growing threat of multidrug-resistant bacteria (MDR). the authors used in silico virtual screening to target MDR Pseudomonas aeruginosa. They considered a key protein in its biosynthesis and virtually screened 20,000 candidates and 30 derivatives of brequinar. In the end, they identified a possible candidate with the highest degree of potential to inhibit the pathogen's lipid A synthesis.

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A Temperature-Based Comparison of Compounds Found in Bao Chong Tea, Green Tea, and Black Tea

Lin et al. | May 14, 2019

A Temperature-Based Comparison of Compounds Found in Bao Chong Tea, Green Tea, and Black Tea

While tea has a complex history, recently the health benefits of this beverage have come into focus. In this study, researchers sought to compare the levels of caffeine, catechins and L-theanine between different types of tea using NMR spectroscopy. Further, the impact of brewing temperature on the release of these compounds was also assessed. Of those tested, Bao Chong tea had the highest levels of these compounds. Brewing temperatures between 45ºC and 75ºC were found to be optimal for compound release. These results can help consumers make informed choices about their tea preparation and intake.

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