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Machine learning on crowd-sourced data to highlight coral disease

Narayan et al. | Jul 26, 2021

Machine learning on crowd-sourced data to highlight coral disease

Triggered largely by the warming and pollution of oceans, corals are experiencing bleaching and a variety of diseases caused by the spread of bacteria, fungi, and viruses. Identification of bleached/diseased corals enables implementation of measures to halt or retard disease. Benthic cover analysis, a standard metric used in large databases to assess live coral cover, as a standalone measure of reef health is insufficient for identification of coral bleaching/disease. Proposed herein is a solution that couples machine learning with crowd-sourced data – images from government archives, citizen science projects, and personal images collected by tourists – to build a model capable of identifying healthy, bleached, and/or diseased coral.

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The Development and Maximization of a Novel Photosynthetic Microbial Fuel Cell Using Rhodospirillum rubrum

Gomez et al. | Mar 02, 2014

The Development and Maximization of a Novel Photosynthetic Microbial Fuel Cell Using <em>Rhodospirillum rubrum</em>

Microbial fuel cells (MFCs) are bio-electrochemical systems that utilize bacteria and are promising forms of alternative energy. Similar to chemical fuel cells, MFCs employ both an anode (accepts electrons) and a cathode (donates electrons), but in these devices the live bacteria donate the electrons necessary for current. In this study, the authors assess the functionality of a photosynthetic MFC that utilizes a purple non-sulfur bacterium. The MFC prototype they constructed was found to function over a range of environmental conditions, suggesting its potential use in industrial models.

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Aberrant response to dexamethasone suppression test associated with inflammatory response in MDD patients

Ulery et al. | Nov 06, 2023

Aberrant response to dexamethasone suppression test associated with inflammatory response in MDD patients

Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.

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Investigating ecosystem resiliency in different flood zones of south Brooklyn, New York

Ng et al. | Mar 23, 2024

Investigating ecosystem resiliency in different flood zones of south Brooklyn, New York
Image credit: Ng and Zheng et al 2024

With climate change and rising sea levels, south Brooklyn is exposed to massive flooding and intense precipitation. Previous research discovered that flooding shifts plant species distribution, decreases soil pH, and increases salt concentration, nitrogen, phosphorus, and potassium levels. The authors predicted a decreasing trend from Zone 1 to 6: high-pH, high-salt, and high-nutrients in more flood-prone areas to low-pH, low-salt, and low-nutrient in less flood-prone regions. They performed DNA barcoding to identify plant species inhabiting flood zones with expectations of decreasing salt tolerance and moisture uptake by plants' soil from Zones 1-6. Furthermore, they predicted an increase in invasive species, ultimately resulting in a decrease in biodiversity. After barcoding, they researched existing information regarding invasiveness, ideal soil, pH tolerance, and salt tolerance. They performed soil analyses to identify pH, nitrogen (N), phosphorus (P), and potassium (K) levels. For N and P levels, we discovered a general decreasing trend from Zone 1 to 6 with low and moderate statistical significance respectively. Previous studies found that soil moisture can increase N and P uptake, helping plants adopt efficient resource-use strategies and reduce water stress from flooding. Although characteristics of plants were distributed throughout all zones, demonstrating overall diversity, the soil analyses hinted at the possibility of a rising trend of plants adapting to the increase in flooding. Future expansive research is needed to comprehensively map these trends. Ultimately, investigating trends between flood zones and the prevalence of different species will assist in guiding solutions to weathering climate change and protecting biodiversity in Brooklyn.

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The Effect of Different Fructose Diets on the Lifespan of C. elegans

Chen et al. | May 10, 2020

The Effect of Different Fructose Diets on the Lifespan of <em>C. elegans</em>

High-fructose diets consumed widely in modern societies predisposes to metabolic diseases such as diabetes. Using the worm C. elegans, the authors of this study investigated the effect of fructose on the worm's survival rates. They found that worms fed 15% fructose had a lower life expectancy than those on a fructose-free diet. These results suggest that, like in humans, fructose has a negative effect on worm survival, which makes them an easy, attractive model to study the effects of fructose on health.

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Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme

Sriram et al. | Sep 27, 2022

Contrasting role of <i>ASCC3</i> and <i>ALKBH3</i> in determining genomic alterations in Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.

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Analyzing resilience in a sample population as a novel qualifier for triage in psychological first aid

Ramesh et al. | Apr 18, 2023

Analyzing resilience in a sample population as a novel qualifier for triage in psychological first aid
Image credit: Mat Napo

While serving as an immediate address for psychological safety and stability, psychological first aid (PFA) currently lacks the incorporation of triage. Without triage, patients cannot be prioritized in correspondence to condition severity that is often called for within emergency conditions. To disentangle the relevance of a potential triage system to PFA, the authors of this paper have developed a method to quantify resilience - a prominent predictor of the capability to recover from a disaster. With this resilience index, they have quantified resilience of differing age, race, and sex demographics to better inform the practice of PFA and potential demographic prioritization via a triage system.

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Grammatical Gender and Politics: A Comparison of French and English in Political Discourse

Zhang et al. | Jul 07, 2021

Grammatical Gender and Politics: A Comparison of French and English in Political Discourse

Grammatical gender systems are prevalent across many languages, and when comparing French and English the existence of this system becomes a strong distinction. There have been studies that attribute assigned grammatical gender with the ability to influence conceptualization (attributing gender attributes) of all nouns, thus affecting people's thoughts on a grand scale. We hypothesized that due to the influence of a grammatical gender system, French political discourse would have a large difference between the number of masculine and feminine nouns used. Specifically, we predicted there would be a larger ratio of feminine to masculine nouns in French political discourse than in non-political discourse when compared to English discourse. Through linguistic analysis of gendered nouns in French political writing, we found that there is a clear difference between the number of feminine versus masculine nouns, signaling a preference for a more “effeminate” language.

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A Retrospective Study of Research Data on End Stage Renal Disease

Ponnaluri et al. | Mar 09, 2016

A Retrospective Study of Research Data on End Stage Renal Disease

End Stage Renal Disease (ESRD) is a growing health concern in the United States. The authors of this study present a study of ESRD incidence over a 32-year period, providing an in-depth look at the contributions of age, race, gender, and underlying medical factors to this disease.

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