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Transcriptomic profiling identifies differential gene expression associated with childhood abuse

Li et al. | Jul 23, 2024

Transcriptomic profiling identifies differential gene expression associated with childhood abuse
Image credit: The authors

Childhood abuse has severe and lasting effects throughout an individual's life, and may even have long-term biological effects on individuals who suffer it. To learn more about the effects of abuse in childhood, Li and Yearwood analyze gene expression data to look for genes differentially expressed genes in individuals with a history of childhood abuse.

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Using Gravitational Waves to Determine if Primordial Black Holes are Sources of Dark Matter

Sivakumar et al. | Jul 15, 2024

Using Gravitational Waves to Determine if Primordial Black Holes are Sources of Dark Matter

In the quest to understand dark matter, scientists face a profound mystery. Two compelling candidates, Massive Compact Halo Objects (MACHOs) and Weakly Interacting Massive Particles (WIMPs), have emerged as potential sources. By analyzing gravitational waves from binary mergers involving these black holes, authors sought to determine if MACHOs could be the elusive dark matter.

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The effects of age on quality of mental health during the COVID-19 pandemic

Bui et al. | Jul 15, 2024

The effects of age on quality of mental health during the COVID-19 pandemic

The impact of age on mental health is a crucial yet understudied aspect of public health. While mental health is gaining recognition as a vital component of overall well-being, its correlation with age remains largely unexplored. In Canada, where the median age has risen significantly over the past half-century, understanding this relationship becomes increasingly pertinent. Researchers hypothesized that older adults would exhibit lower rates of mental health disorders and report better perceived mental health due to increased emotional stability and maturity.

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Mechanistic deconvolution of autoreduction in tetrazolium-based cell viability assays

Tran et al. | Jul 12, 2024

Mechanistic deconvolution of autoreduction in tetrazolium-based cell viability assays

Optical reporters like tetrazolium dyes, exemplified by 5-diphenyl tetrazolium bromide (MTT), are effective tools for quantifying cellular responses under experimental conditions. These dyes assess cell viability by producing brightly-colored formazan dyes when reduced inside active cells. However, certain small molecules, including reducing agents like ascorbic acid, cysteine, and glutathione (GSH), can interfere with MTT assays, potentially compromising accuracy.

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Optical anisotropy of crystallized vanillin thin film: the science behind the art

Wang et al. | Jul 09, 2024

Optical anisotropy of crystallized vanillin thin film: the science behind the art
Image credit: The authors

Microscopic beauty is hiding in common kitchen ingredients - even vanillin flavoring can be turned into mesmerizing artwork by crystallizing the vanillin and examining it under a polarizing microscope. Wang and Pang explore this hidden beauty by determining the optimal conditions to grow crystalline vanillin films and by creating computer simulations of chemical interactions between vanillin molecules.

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Can the attributes of an app predict its rating?

Feng et al. | Jul 03, 2024

Can the attributes of an app predict its rating?
Image credit: Mika Baumeister

In this article the authors looked at different attributes of apps within the Google Play store to determine how those may impact the overall app rating out of five stars. They found that review count, amount of storage needed and when the app was last updated to be the most influential factors on an app's rating.

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Substance Abuse Transmission-Impact of Parental Exposure to Nicotine/Alcohol on Regenerated Planaria Offspring

Bennet et al. | Jul 02, 2024

Substance Abuse Transmission-Impact of Parental Exposure to Nicotine/Alcohol on Regenerated Planaria Offspring

The global mental health crisis has led to increased substance abuse among youth. Prescription drug abuse causes approximately 115 American deaths daily. Understanding intergenerational transmission of substance abuse is complex due to lengthy human studies and socioeconomic variables. Recent FDA guidelines mandate abuse liability testing for neuro-active drugs but overlook intergenerational transfer. Brown planaria, due to their nervous system development similarities with mammals, offer a novel model.

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