Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.

FBS is an important component in in vitro cell culture work, helping to provide needed nutrients to cells to grow. The authors look at the ability of an alternative to FBS to support cell growth in culture.