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Development of selective RAC1/KLRN inhibitors

Kubrat Neczaj-Hruzewicz et al. | Nov 04, 2024

Development of selective RAC1/KLRN inhibitors

Kalirin is a guanine nucleotide exchange factor (GEF) for the GTPase RAC1, linked to schizophrenia and Alzheimer’s Disease. It plays a crucial role in synaptic plasticity by regulating dendritic spine formation and actin cytoskeleton remodeling, which are essential for creating new synapses. Authors developed two novel compounds targeting kalirin, confirming that predictive modeling can indicate biological activity.

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Enhanced brain arteries and aneurysms analysis using a CAE-CFD approach

Saravanan et al. | Mar 02, 2025

Enhanced brain arteries and aneurysms analysis using a CAE-CFD approach
Image credit: Vineet Saravanan

Here, recognizing that brain aneurysms pose a severe threat, often misdiagnosed and leading to high mortality, particularly in younger individuals, the authors explored a novel computer-aided engineering approach. They used magnetic resonance angiography images and computational fluid dynamics, to improve aneurysm detection and risk assessment, aiming for more personalized treatment.

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A novel approach for early detection of Alzheimer’s disease using deep neural networks with magnetic resonance imaging

Ganesh et al. | Mar 20, 2022

A novel approach for early detection of Alzheimer’s disease using deep neural networks with magnetic resonance imaging

In the battle against Alzheimer's disease, early detection is critical to mitigating symptoms in patients. Here, the authors use a collection of MRI scans, layering with deep learning computer modeling, to investigate early stages of AD which can be hard to catch by human eye. Their model is successful, able to outperform previous models, and detected regions of interest in the brain for further consideration.

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Ladder Fuel Treatments Effect Burn Area of Forest Fires in Semi-Arid High Elevation Climates

Schwartz et al. | Oct 05, 2020

Ladder Fuel Treatments Effect Burn Area of Forest Fires in Semi-Arid High Elevation Climates

In this study, the authors investigate a timely and important topic: forest fires. More specifically, they use a wildfire simulator to test how ladder fuels effect the burn area of a forest fire. Ladder fuels are fuels that cause a forest fire to rise up from the forest floor to the canopy, which may affect the overall spread. They simulated fire spread with different levels of ladder fuel treatment and found that the spread of a burn area would indeed decrease with increased ladder fuel treatment. These findings have important implications for forest and forest fire management.

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