![DNA repair protein mutations alter blood cancer sensitivity to cisplatin or gemcitabine <i>in vitro</i>](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBbDRQIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--1e6674c4fbc22e735ba20180d3a1fc8c9aa3b587/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/feature.jpg)
The authors investigate whether human blood cancers carrying mutations in DNA repair genes possess increased sensitivity to common chemotherapy drugs cisplatin or gemcitabine.
Read More...DNA repair protein mutations alter blood cancer sensitivity to cisplatin or gemcitabine in vitro
The authors investigate whether human blood cancers carrying mutations in DNA repair genes possess increased sensitivity to common chemotherapy drugs cisplatin or gemcitabine.
Read More...Analyzing breath sounds by using deep learning in diagnosing bronchial blockages with artificial lung
Many common respiratory illnesses like bronchitis, asthma, and chronic obstructive pulmonary disease (COPD) lead to bronchial inflammation and, subsequently, a blockage. However, there are many difficulties in measuring the severity of the blockage. A numeric metric to determine the degree of the blockage severity is necessary. To tackle this demand, we aimed to develop a novel human respiratory model and design a deep-learning program that can constantly monitor and report bronchial blockage by recording breath sounds in a non-intrusive way.
Read More...TGFβ1 Codon 10 Polymorphism and its Association with the Prevalence of Low Myopia
The goal of this project was to assess the relationships among low myopia, behavioral and demographic factors, and a single-nucleotide polymorphism (SNP) in the TGFβ1 gene.
Read More...Automated classification of nebulae using deep learning & machine learning for enhanced discovery
There are believed to be ~20,000 nebulae in the Milky Way Galaxy. However, humans have only cataloged ~1,800 of them even though we have gathered 1.3 million nebula images. Classification of nebulae is important as it helps scientists understand the chemical composition of a nebula which in turn helps them understand the material of the original star. Our research on nebulae classification aims to make the process of classifying new nebulae faster and more accurate using a hybrid of deep learning and machine learning techniques.
Read More...Bacteroides thetaiotaomicron Growth Numbers Are Unchanged in the Presence of Yogurt
Disruptions to the microbiome, specifically the imbalance in the two major phyla, the Firmicutes and the Bacteroidetes, have been linked to the development of obesity. This study explored whether or not Fage plain total 0% Greek yogurt, which contains live and active bacterial cultures belonging to the Firmicute phylum, could decrease the numbers of Bacteroides thetaiotaomicron, an organism found in the human gut that belongs to the Bacteroidetes phylum.
Read More...Artificial Intelligence Networks Towards Learning Without Forgetting
In their paper, Kreiman et al. examined what it takes for an artificial neural network to be able to perform well on a new task without forgetting its previous knowledge. By comparing methods that stop task forgetting, they found that longer training times and maintenance of the most important connections in a particular task while training on a new one helped the neural network maintain its performance on both tasks. The authors hope that this proof-of-principle research will someday contribute to artificial intelligence that better mimics natural human intelligence.
Read More...Glyphosate Levels in American Food Products Meet Government Safety Levels Yet Exceed Concentrations Associated with Negative Effects
Glyphosate is the active ingredient in the herbicide Roundup, frequently used in the agricultural industry worldwide. Current literature reveals contradictory findings regarding the effects of glyphosate on vertebrates, leading to concerns about human consumption and differing views on safety levels. Here, authors sought to measure glyphosate levels in common commercially available food products. While some product levels exceed the thresholds at which negative effects have been observed, none exceed government limits.
Read More...Studying habitability of the exoplanents Kepler-504 b, Kepler-315 b, and Kepler-315 c
The authors explore how similar exoplanets are to Earth and whether they could be inhabited by humans and other living organisms.
Read More...Substance Abuse Transmission-Impact of Parental Exposure to Nicotine/Alcohol on Regenerated Planaria Offspring
The global mental health crisis has led to increased substance abuse among youth. Prescription drug abuse causes approximately 115 American deaths daily. Understanding intergenerational transmission of substance abuse is complex due to lengthy human studies and socioeconomic variables. Recent FDA guidelines mandate abuse liability testing for neuro-active drugs but overlook intergenerational transfer. Brown planaria, due to their nervous system development similarities with mammals, offer a novel model.
Read More...The Role of Corresponding Race, Gender, and Species as Incentives for Charitable Giving
Inherent bias is often the unconscious driver of human behavior, and the first step towards overcoming these biases is our awareness of them. In this article the authors investigate whether race, gender or species affect the choice of charity by middle class Spaniards. Their conclusions serve as a starting point for further studies that could help charities refine their campaigns in light of these biases effectively transcending them or taking advantage of them to improve their fundraising attempts.
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