The authors looked at the impacts of short-chain fatty acids on muscle fiber formation as well as insulin sensitivity using a model of mouse myoblasts.
Read More...Investigating the impact of short-chain fatty acids on myofiber dynamics and insulin sensitivity
The authors looked at the impacts of short-chain fatty acids on muscle fiber formation as well as insulin sensitivity using a model of mouse myoblasts.
Read More...Understanding investors behaviors during the COVID-19 outbreak using Twitter sentiment analysis
The authors examine a relationship between tweet sentiment and stock market behavior during the early weeks of the COVID-19 pandemic.
Read More...Quantifying natural recovery of dopamine deficits induced by chronic stress
Here the authors investigated the natural recovery of stress-induced dopamine-related gene deficits in C. elegans by measuring the expression of cat-2 (dopamine biosynthesis) and sod-2 (oxidative stress) following exposure to starvation or hydrocortisone. They found that the reversibility of sod-2 and the expression of cat-2 were highly dependent on the type and severity of the stressor, suggesting that the body's natural ability to recover from dopamine dysfunction has biological limitations.
Read More...The effect of youth marijuana use on high-risk drug use: Examining gateway and substitution hypothesis
The authors looked at whether youth use of marijuana related to later high-risk drug use. Using survey data from 2010-2019 they found that youth marijuana use did correlate to an increased risk of high-risk drug use.
Read More...The precision of machine learning models at classifying autism spectrum disorder in adults
Autism spectrum disorder (ASD) is hard to correctly diagnose due to the very subjective nature of diagnosing it: behavior analysis. Due to this issue, we sought to find a machine learning-based method that diagnoses ASD without behavior analysis or helps reduce misdiagnosis.
Read More...Cocktail therapy to inhibit multispecies biofilm in cystic fibrosis patients
Here, recognizing the important role of bacterial biofilms in many life-threatening chronic infections, the authors investigated the effectiveness of a combination treatment on biofilms composed of up to three different common species within the lungs of cystic fibrosis patients with computational analysis. They found that a triple cocktail therapy targeting three different signaling pathways has significant potential as both a treatment and prophylaxis.
Read More...Using the COmplex PAthway SImulator, Stage Analysis, and Chemical Kinetics to Develop a Novel Solution to Lower Tau Concentrations in Alzheimer’s Disease
In this study, the authors ask whether a Tau immunotherapy treatment, Hsp70 protein treatment, or dual treatment approach of both the Tau imunotherapy treatment and Hsp70 protein treatment leads to a greater reduction in Tau protein concentration in Alzheimer's disease. Overall, they conclude that the effectiveness of the treatment ultimately relies on the stage of Alzheimer’s.
Read More...Pancreatic Adenocarcinoma: An Analysis of Drug Therapy Options through Interaction Maps and Graph Theory
Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.
Read More...Characterization of Inflammatory Cytokine Gene Expression in a Family with a History of Psoriasis
Psoriasis is a heritable autoimmune disorder characterized by abnormal red and itchy skin patches. The authors study the family of a man with psoriasis. They explore whether the man's children, who do not show any symptoms of psoriasis, demonstrate gene expression consistent with the disease.
Read More...Predicting sickle cell vaso-occlusion by microscopic imaging and modeling
The authors use blood smears from individuals with sickle cell disease to correlate sickle cell frequency with the occurrence of vaso-occlusive crises.
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