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What is the optimal fuel for space flight? Efficiency, cost, and environmental impact

Kapitonova et al. | Dec 28, 2023

What is the optimal fuel for space flight? Efficiency, cost, and environmental impact
Image credit: NASA

Here, the authors sought to investigate the efficiency, cost, and environmental impact of several possible propellants that are or could be used for space flight. By deriving three novel equations, they identified harm, energy, and cost scores for each fuel, suggesting that considering each factor will be essential to the ongoing growth of the space industry.

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Developing anticholinergic drugs for the treatment of asthma with improved efficacy

Wong et al. | Jul 05, 2023

Developing anticholinergic drugs for the treatment of asthma with improved efficacy
Image credit: Wong et al.

Anticholinergics are used in treating asthma, a chronic inflammation of the airways. These drugs block human M1 and M2 muscarinic acetylcholine receptors, inhibiting bronchoconstriction. However, studies have reported complications of anticholinergic usage, such as exacerbated eosinophil production and worsened urinary retention. Modification of known anticholinergics using bioisosteric replacements to increase efficacy could potentially minimize these complications. The present study focuses on identifying viable analogs of anticholinergics to improve binding energy to the receptors compared to current treatment options. Glycopyrrolate (G), ipratropium (IB), and tiotropium bromide (TB) were chosen as parent drugs of interest, due to the presence of common functional groups within the molecules, specifically esters and alcohols. Docking score analysis via AutoDock Vina was used to evaluate the binding energy between drug analogs and the muscarinic acetylcholine receptors. The final results suggest that G-A3, IB-A3, and TB-A1 are the most viable analogs, as binding energy was improved when compared to the parent drug. G-A4, IB-A4, IB-A5, TB-A3, and TB-A4 are also potential candidates, although there were slight regressions in binding energy to both muscarinic receptors for these analogs. By researching the effects of bioisosteric replacements of current anticholinergics, it is evident that there is a potential to provide asthmatics with more effective treatment options.

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Efficient synthesis of superabsorbent beads using photopolymerization with a low-cost method

Wang et al. | Jun 09, 2023

Efficient synthesis of superabsorbent beads using photopolymerization with a low-cost method

Superabsorbent beads are remarkable, used throughout our daily lives for various practical applications. These beads, as suggested by their name, possess a unique ability to absorb and retain large quantities of liquids. This characteristic of absorbency makes them essential throughout the medical field, agriculture, and other critical industries as well as in everyday products. To create these beads, the process of photopolymerization is fast growing in favor with distinct advantages of cost efficiency, speed, energy efficiency, and mindfulness towards the environment. In this article, researchers explore the pairing of cheap monomers with accessible equipment for creation of superabsorbent beads via the photopolymerization process. This research substantially demonstrates the successful application of photopolymerization in producing highly absorbent beads in a low-cost context, thereby expanding the accessibility of this process for creating superabsorbent beads in both research and practical applications.

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Effects of an Informational Waste Management App on a User’s Waste Disposal Habits

Rao et al. | Apr 28, 2021

Effects of an Informational Waste Management App on a User’s Waste Disposal Habits

While 75% of waste in the United States is stated to be recyclable, only about 34% truly is. This project takes a stance to combat the pillars of mismanaged waste through a modern means of convenience: the TracedWaste app. The purpose of this study was to identify how individuals' waste disposal habits improved and knowledge increased (i.e. correctly disposing of waste, understanding negative incorrect waste disposal) due to their use of an informational waste management app as measured by a survey using a 1-5 Likert Scale. The results showed that the TracedWaste app helped conserve abundant resources such as energy and wood, decrease carbon emissions, and minimize financial toll all through reducing individual impact.

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Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Sun et al. | Dec 18, 2020

Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.

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Leveraging E-Waste to Enhance Water Condensation by Effective Use of Solid-state Thermoelectric Cooling

Joshi et al. | Dec 02, 2020

Leveraging E-Waste to Enhance Water Condensation by Effective Use of Solid-state Thermoelectric Cooling

Water scarcity affects upwards of a billion people worldwide today. This project leverages the potential of capturing humidity to build a high-efficiency water condensation device that can generate water and be used for personal and commercial purposes. This compact environment-friendly device would have low power requirements, which would potentially allow it to utilize renewable energy sources and collect water at the most needed location.

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Temperature and Precipitation Responses to a Stratospheric Aerosol Geoengineering Experiment Using the Community Climate System Model 4

Anderson et al. | Aug 19, 2014

Temperature and Precipitation Responses to a Stratospheric Aerosol Geoengineering Experiment Using the Community Climate System Model 4

We are changing our environment with steadily increasing carbon dioxide emissions, but we might be able to help. The authors here use a computer program called Community Climate System Model 4 to predict the effects of spraying small particles into the atmosphere to reflect away some of the sun's rays. The software predicts that this could reduce the amount of energy the Earth's atmosphere absorbs and may limit but will not completely counteract our carbon dioxide production.

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