The authors developed and tested machine learning methods to diagnose tuberculosis from pulmonary X-ray scans.
Read More...Effects of data amount and variation in deep learning-based tuberculosis diagnosis in chest X-ray scans
The authors developed and tested machine learning methods to diagnose tuberculosis from pulmonary X-ray scans.
Read More...Investigating auxin import and export proteins in Chlorella vulgaris
This study explores auxin signaling in Chlorella vulgaris, a green alga with potential for sustainable biofuel and food production. Evidence from protoplast swelling experiments suggests that C. vulgaris secretes auxin and possesses auxin import proteins, highlighting previously uncharacterized signaling pathways. These findings could support more efficient cultivation and resource extraction strategies.
Read More...Impact of Silverado Fire on soil carbon
Soil stores three times more carbon than the atmosphere, making small changes in its storage and release crucial for carbon cycling and climate models. This study examined the impact of the 2020 California Silverado Fire on pyrogenic carbon (PyC) deposits using nitrogen and carbon isotopes as proxies. While the results showed significant variability in δ¹⁵N, δ¹³C, total carbon, and total nitrogen across sites, they did not support the hypothesis that wildfire increases δ¹⁵N while keeping δ¹³C constant, emphasizing the need for location-based controls when using δ¹⁵N to track PyC.
Read More...SOS-PVCase: A machine learning optimized lignin peroxidase with polyvinyl chloride (PVC) degrading properties
The authors looked at the primary structure of lignin peroxidase in an attempt to identify mutations that would improve both the stability and solubility of the peroxidase protein. The goal is to engineer peroxidase enzymes that are stable to help break down polymers, such as PVC, into monomers that can be reused instead of going to landfills.
Read More...Intra and interspecies control of bacterial growth through extracellular extracts
The study discusses the relationship between bacterial species and the human gut microbiome, emphasizing the role of quorum sensing molecules in bacterial communication and its implications for health. Authors investigated the impact of bacterial supernatants from Escherichia coli (E. coli) on the growth of new E. coli and Enterobacter aerogenes (E. aerogenes) cultures.
Read More...Polluted water tested from the Potomac River affects invasive species plant growth
Here recognizing the potential for pollution to impact the ecosystems of local waterways, the authors investigated the growth of tiger lilies, which are invasive to the Potomac River, in relation to the level of pollution. The authors report that increasing levels of pollution led to increased growth of the invasive species based on their study.
Read More...Virtual Screening of Cutibacterium acnes Antibacterial Agent Using Natural Compounds Database
A common form of Acne is caused by a species of bacterium called Cutibacterium acnes. By using a predictive algorithm and structural analysis, the authors identified 5 small molecules with high affinity to growth factors in Catibacterium acnes. This has potential implications for supplemental skincare products.
Read More...Fire and dry grass: Effects of Pennisetum villosum on a California native, Nassella pulchra, in drought times
Invasive species pose a significant threat to many ecosystems, whether by outcompeting native species and disturbing food webs, or through increasing risks of natural disasters like flooding and wildfires. The ornamental grass species Pennisetum villosum R. Br. was previously identified by the California Invasive Plant Council as being potentially invasive; this experiment was conducted to determine if P. villosum displays characteristics of an invasive species when grown in a California chaparral environment. Reults found that in both conditions, the two species had similar germination rates, and that P. villosum grew significantly larger than N. pulchra for around 95 days.
Read More...Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence
Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.
Read More...Sepia bandensis ink inhibits polymerase chain reactions
While cephalopods play significant roles in both ecosystems and medical research, there is currently no assembled genome. In an attempt to sequence the Sepia bandensis genome, it was found that there was inhibition from the organism during DNA extraction, resulting in PCR failure. In this study, researchers tested the hypothesis that S. bandensis ink inhibits PCR. They then assessed the impact of ink on multiple methods of DNA extraction
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