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Impact of simple vs complex carbohydrates under time constraint before anaerobic and aerobic exercise

Cui et al. | Oct 13, 2022

Impact of simple vs complex carbohydrates under time constraint before anaerobic and aerobic exercise

The goal of this study was to determine the if carbohydrates or complex carbohydrates are better for athlete's performance in anaerobic and aerobic exercise. Ultimately, we found that, when one’s schedule only allows for 30 minutes to eat before a workout, the best pre-workout meal for optimal glycogen levels to prompt muscle hypertrophy, strength increases, and better endurance is one that is simple carbohydrate-heavy.

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The effects of Helianthus Annuus on Amyotrophic Lateral Sclerosis using Drosophila Melanogaster

Srinivasan et al. | Oct 13, 2022

The effects of <em>Helianthus Annuus</em> on Amyotrophic Lateral Sclerosis using <em>Drosophila Melanogaster</em>

Amyotrophic lateral sclerosis (ALS) affects nearly 200,000 people worldwide and there is currently no cure. The purpose of the study was to determine if Helianthus annuus seeds helped reduce nerve degeneration and increase locomotion using Drosophila melanogaster as the model organism. Through this experiment, we found a general trend suggesting that H. annuus helped increase the mobility of the D. melanogaster suggesting it could be a viable supplement for patients with ALS.

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Computational development of aryl sulfone compounds as potential NNRTIs

Zhang et al. | Oct 12, 2022

Computational development of aryl sulfone compounds as potential NNRTIs

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors that bind to the HIV reverse transcriptase and prevent replication. Indolyl aryl sulfones (IAS) and IAS derivatives have been found to be highly effective against mutant strains of HIV-1 reverse transcriptase. Here, we analyzed molecules designed using aryl sulfone scaffolds paired to cyclic compounds as potential NNRTIs through the computational design and docking of 100 novel NNRTI candidates. Moreover, we explored the specific combinations of functional groups and aryl sulfones that resulted in the NNRTI candidates with the strongest binding affinity while testing all compounds for carcinogenicity. We hypothesized that the combination of an IAS scaffold and pyrimidine would produce the compounds with the best binding affinity. Our hypothesis was correct as the series of molecules with an IAS scaffold and pyrimidine exhibited the best average binding affinity. Additionally, this study found 32 molecules designed in this procedure with higher or equal binding affinities to the previously successful IAS derivative 5-bromo-3-[(3,5-dimethylphenyl)sulfonyl]indole-2-carboxyamide when docked to HIV-1 reverse transcriptase.

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Refinement of Single Nucleotide Polymorphisms of Atopic Dermatitis related Filaggrin through R packages

Naravane et al. | Oct 12, 2022

Refinement of Single Nucleotide Polymorphisms of Atopic Dermatitis related Filaggrin through R packages

In the United States, there are currently 17.8 million affected by atopic dermatitis (AD), commonly known as eczema. It is characterized by itching and skin inflammation. AD patients are at higher risk for infections, depression, cancer, and suicide. Genetics, environment, and stress are some of the causes of the disease. With the rise of personalized medicine and the acceptance of gene-editing technologies, AD-related variations need to be identified for treatment. Genome-wide association studies (GWAS) have associated the Filaggrin (FLG) gene with AD but have not identified specific problematic single nucleotide polymorphisms (SNPs). This research aimed to refine known SNPs of FLG for gene editing technologies to establish a causal link between specific SNPs and the diseases and to target the polymorphisms. The research utilized R and its Bioconductor packages to refine data from the National Center for Biotechnology Information's (NCBI's) Variation Viewer. The algorithm filtered the dataset by coding regions and conserved domains. The algorithm also removed synonymous variations and treated non-synonymous, frameshift, and nonsense separately. The non-synonymous variations were refined and ordered by the BLOSUM62 substitution matrix. Overall, the analysis removed 96.65% of data, which was redundant or not the focus of the research and ordered the remaining relevant data by impact. The code for the project can also be repurposed as a tool for other diseases. The research can help solve GWAS's imprecise identification challenge. This research is the first step in providing the refined databases required for gene-editing treatment.

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Photometric analysis and light curve modeling of apparent transient 2020pni

Arora et al. | Oct 07, 2022

Photometric analysis and light curve modeling of apparent transient 2020pni

Supernovas are powerful explosions that result from gravitational collapse of a massive star. Using photometric analysis Arora et al. set out to investigate whether 2020pni (located in galaxy UGC 9684) was a supernova. They were ultimately able to identify 2020pni as a Type II-L supernova and determine it's distance from earth.

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The effect of adverse childhood experiences on e-cigarette usage in people aged 18–30 in the US

Bloomer et al. | Oct 06, 2022

The effect of adverse childhood experiences on e-cigarette usage in people aged 18–30 in the US

Recently, e-cigarette usage has been increasing rapidly. Previous research has found that adverse
childhood experiences (ACEs) are correlated to cigarette usage. However, there is limited data exploring if ACEs affect vaping. Therefore, in this work, we investigated the effects of ACEs on e-cigarette usage and hypothesize that witnessing vaping in the house and facing ACEs would increase e-cigarette usage while education on the dangers of vaping would decrease e-cigarette usage. We found that different types of ACEs had different correlations with e-cigarette usage and that education on the dangers of vaping had no effect on e-cigarette usage.

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Societal awareness regarding viral Hepatitis in developed and developing countries

Srivastava et al. | Oct 03, 2022

Societal awareness regarding viral Hepatitis in developed and developing countries

Many cases of viral hepatitis are easily preventable if caught early; however, a lack of public awareness regarding often leads to diagnoses near the final stages of disease when it is most lethal. Thus, we wanted to understand to what extent an individual's sex, age, education and country of residence (India or Singapore) impacts disease identification. We sent out a survey and quiz to residents in India (n = 239) and Singapore (n = 130) with questions that test their knowledge and awareness of the disease. We hypothesized that older and more educated individuals would score higher because they are more experienced, but that the Indian population will not be as knowledgeable as the Singaporean population because they do not have as many resources, such as socioeconomic access to schools and accessibility to healthcare, available to them. Additionally, we predicted that there would not be any notable differences between make and females. The results revealed that the accuracy for all groups we looked at was primarily below 50%, demonstrating a severe knowledge gap. Therefore, we concluded that if more medical professionals discussed viral hepatitis during hospital visits and in schools, patients can avoid the end stages of the disease in notable cases.

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Does technology help or hurt learning? Evidence from middle school and high school students

Lu et al. | Oct 02, 2022

Does technology help or hurt learning? Evidence from middle school and high school students

Here, recognizing the vastly different opinion held regarding device usage, the authors considered the effects of technology use on middle and high school students' learning effectiveness. Using an anonymous online survey they found partial support that device use at school increases learning effectiveness, but found strong support for a negative effect of technology use at home on learning effectiveness. Based on their findings they suggest that the efficacy of technology depends on environmental context along with other important factors that need consideration.

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