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Enzyme chemotaxis is a thermodynamic phenomenon in which enzymes move along a substrate concentration gradient towards regions with higher substrate concentrations and can be used to steer nanovehicles towards targets along natural substrate concentrations. In patients with Alzheimer’s disease, a gradient of tau protein forms in the bloodstream. Tau protein is a substrate of the enzyme CDK5, which catalyzes the phosphorylation of tau protein and can travel using chemotaxis along tau protein gradients to increasing concentrations of tau and amyloid-beta proteins. The authors hypothesized that CDK5 would be able to overcome these barriers of Brownian motion and developed a quantitative model using Michaelis-Menten kinetics to define the necessary parameters to confirm and characterize CDK5’s chemotactic behavior to establish its utility in drug delivery and other applications.

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

Vibrio fischeri is an amazing species of bacteria that lives symbiotically in the light organ of luminescent bobtail squid. In this study, authors study the strength and optimal conditions for V. fischeri light production, and assess whether this luminescence could be a natural light source comparable to manmade lighting.

Minimal Change Disease (MCD) is a degenerative kidney disease. Researchers know very little about the cause of this disorder, however some research has suggested that T lymphocytes may be involved. In this study, the authors measure CD4 and CD8 T cell subpopulations in patients with MCD to investigate whether irregular T lymphocyte populations may be involved in MCD pathogenesis.

The authors looked at different strategies to extract oil from almonds to determine which gave the best results.

The authors computationally screened potential ALDH1 inhibitors, for use as potential cancer therapeutics.

In this study, the authors investigate the effects that microplastics (which pollute fresh and saltwater ecosystems) have on plankton species Daphnia Magna by measuring their movement and viability.

Oil spills are one of the most devastating events for marine life. Finding ways to clean up oil spills without the need for harsh chemicals could help decrease the negative impact of such spills. Here the authors demonstrate that using a combination of several biodegradable substances can effectively adsorb oil in seawater in a laboratory setting. They suggest further exploring the potential of such a combination as a possible alternative to commonly-used non-biodegradable substances in oil spill management.

Alzheimer’s disease (AD) is a type of dementia that affects more than 5.5 million Americans, and there are no approved treatments that can delay the advancement of the disease. In this work, Xu and Mitchell test the effects of various herbal extracts (bugleweed, hops, sassafras, and white camphor) on Aβ_1-40 peptide levels in human neuroblastoma cells. Their results suggest that bugleweed may have the potential to reduce Aβ_1-40 levels through its anti-inflammatory properties.

In this study, the authors investigate a timely and important topic: forest fires. More specifically, they use a wildfire simulator to test how ladder fuels effect the burn area of a forest fire. Ladder fuels are fuels that cause a forest fire to rise up from the forest floor to the canopy, which may affect the overall spread. They simulated fire spread with different levels of ladder fuel treatment and found that the spread of a burn area would indeed decrease with increased ladder fuel treatment. These findings have important implications for forest and forest fire management.