Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.

With low-temperature transportation being critical for the progress of research and medical services by preserving biological samples and vaccines, the optimization of cold storage materials is more critical now than ever. The exclusive use of dry ice has its limitations. Notably, it proves insufficient for cold storage during long-range transportation necessary for the delivery of specimens to rural areas. In this article, the authors have proposed a new means of cold storage through the combination of dry ice and ethanol. Upon thorough analysis, the authors have determined their new method as considerably better than the use of pure dry ice across many characteristics, including cold storage capacity, longevity of material, and financial and environmental feasibility.

Here the authors investigated the role of agricultural fertilizers as potential contributors to greenhouse gas emissions. In contrast to the typical investigations that consider microbiological processes, the authors considered purely chemical processes. Based on their results they found that as much as 20.41% of all CO₂ emission from land-based activities could be a result of mineral nitrogen fertilizers.

Naturally occurring neuroactive alkaloids are often studied for their potential to treat Neurological diseases. This team of students study Rivastigmine, a potent cholinesterase inhibitor that is a synthetic analog of physostigmine, which comes from the Calabar bean plant Physostigma venenosum. By comparing the effects of optimized synthetic analogs to the naturally occurring alkaloid, they determine the most favorable analog for inhibition of acetylcholinesterase (AChE), the enzyme that breaks down the neurotransmitter acetylcholine (ACh) to terminate neuronal transmission and signaling between synapses.

Chemicals used in fertilizers and pesticides often end up in nearby bodies of water due to runoff and may have negative impacts on these important ecosystems. In this study, the authors use water containing different nitrogen levels to investigate the effect on the growth of the English daisy.

In this study, the authors determined whether tautomerization dynamics in protic and aprotic solvents displayed differences in reaction rates and in the proportion of the keto and enol tautomers present.

Berberine, a natural product alkaloid, has been shown to exert biological activity via in situ production of singlet oxygen when photo irradiated. Berberine utilizes singlet oxygen in its putative mechanism of action, wherein it forms an activated complex with DNA and photosensitizes triplet oxygen to singlet oxygen to specifically oxidize guanine residues, thereby halting cell replication and leading to cell death. This has potential application in photodynamic therapy, alongside other such compounds which also act as photosensitizers and produce singlet oxygen in situ. The quantification of singlet oxygen in various photosensitizers, including berberine, is essential for determining their photosensitizer efficiencies. We postulated that the singlet oxygen produced by photoirradiation of berberine would be superior in terms of singlet oxygen production to the aforementioned photosensitizers when irradiated with UV light, but inferior under visible light conditions, due to its strong absorbance of UV wavelengths.

This study focused on finding more sustainable growing methods that reduce chemical fertilizer or water usage and can be used at the household level for garden plants. Metrics for healthy plant growth were height at first bloom, growing time, and survival rate. The Deep Water Culture (DWC) treatment for garden cress plants significantly increased the height at first bloom compared to the control group. For rates of surviving plants, the treatments had little effect on garden cress, but the Eggshell Grounds, Wick System, and DWC system groups outperformed the control group for marigolds.

Here, the authors aimed to apply home soil testing to identify the cause of the growth differences between two lemon trees. They hypothesized that differences in physical and chemical soil characteristics were influencing differences in soil productivity and plant growth. Overall, the study demonstrated the effectiveness of home soil testing to characterize soils and help homeowners solve common gardening problems.

The authors tested environmentally-friendly alternatives to wastewater treatment chemicals, including activated charcoal for filtration and citrus peels for preventing bacterial growth.