Browse Articles

The Effect of Cobalt Biomineralization on Power Density in a Microbial Fuel Cell

Bandyopadhyay et al. | Sep 07, 2015

The Effect of Cobalt Biomineralization on Power Density in a Microbial Fuel Cell

A microbial fuel cell is a system to produce electric current using biochemical products from bacteria. In this project authors operated a microbial fuel cell in which glucose was oxidized by Shewanella oneidensis in the anodic compartment. We compared the power output from biomineralized manganese or cobalt oxides, reduced by Leptothrix cholodnii in the cathodic compartment.

Read More...

Effect of the Herbal Formulation HF1 on the Expression of PD-L1 in PC3 cells

Imani et al. | Nov 15, 2019

Effect of the Herbal Formulation HF1 on the Expression of PD-L1 in PC3 cells

In this study, Imani et al. investigate whether a new proprietary herbal formulation, HF1, can inhibit expression of immune suppressor protein PD-L1. PD-L1 is a transmembrane protein that can be expressed by cancer cells to assist in their ability to avoid attacks from the immune system. Work from this study demonstrates that HF1 treatment can reduce expression of PD-L1 in cultured cancer cells, implicating HF1 as a potential new cancer therapy.

Read More...

Conversion of Mesenchymal Stem Cells to Cancer-Associated Fibroblasts in a Tumor Microenvironment: An in vitro Study

Ramesh et al. | Feb 18, 2020

Conversion of Mesenchymal Stem Cells to Cancer-Associated Fibroblasts in a Tumor Microenvironment: An <em>in vitro</em> Study

Mesenchymal stem cells(MSCs) play a role in tumor formation by differentiating into cancer associated fibroblasts (CAFs) which enable metastasis of tumors. The process of conversion of MSCs into CAFs is not clear. In this study, authors tested the hypothesis that cancers cells secrete soluble factors that induce differentiation by culturing bone marrow mesenchymal stem cells in media conditioned by a breast cancer cell line.

Read More...

Luteolin's positive inhibition of melanoma cell lines.

Su et al. | Nov 17, 2020

Luteolin's positive inhibition of melanoma cell lines.

Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a flavonoid that occurs in fruits, vegetables, and herbs. Research suggests that luteolin is effective against various forms of cancer by triggering apoptosis pathways. This experiment analyzes the effects of luteolin on the cell viability of malignant melanoma cells using an in vitro experiment to research alternative melanoma treatments and hopefully to help further cancer research as a whole.

Read More...

Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Lee et al. | Mar 30, 2022

Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

Read More...

In silico modeling of emodin’s interactions with serine/threonine kinases and chitosan derivatives

Suresh et al. | Jan 10, 2022

<i>In silico</i> modeling of emodin’s interactions with serine/threonine kinases and chitosan derivatives

Here, through protein-ligand docking, the authors investigated the effect of the interaction of emodin with serine/threonine kinases, a subclass of kinases that is overexpressed in many cancers, which is implicated in phosphorylation cascades. Through molecular dynamics theyfound that emodin forms favorable interactions with chitosan and chitosan PEG (polyethylene glycol) copolymers, which could aid in loading drugs into nanoparticles (NPs) for targeted delivery to cancerous tissue. Both polymers demonstrated reasonable entrapment efficiencies, which encourages experimental exploration of emodin through targeted drug delivery vehicles and their anticancer activity.

Read More...

Pichia kudriavzevii Yeast Exposure Increases the Asthmatic Behavior of Alveolar Epithelial Cells In Vitro

Ortega et al. | Jun 07, 2019

<em>Pichia kudriavzevii</em> Yeast Exposure Increases the Asthmatic Behavior of Alveolar Epithelial Cells <em>In Vitro</em>

Asthma affects over 334 million people worldwide and is triggered by inhalation of environmental stimuli. The authors of this study characterized the effect of exposure to common spoilage yeast, Pichia kidriavzevii on alveolar epithelial cells. A direct correlation between infection duration and asthmatic status of these cells was found, indicating the potential for this yeast to be an environmental stimulus of asthma and warranting further study.

Read More...

Evaluation of Tea Extract as an Inhibitor of Oxidative Stress in Prostate Cells

Zhang et al. | Jan 22, 2019

Evaluation of Tea Extract as an Inhibitor of Oxidative Stress in Prostate Cells

One important factor that contributes to human cancers is accumulated damage to cells' DNA due to the oxidative stress caused by free radicals. In this study, the authors investigate the effects of several different tea leaf extracts on oxidative stress in cultured human prostate cells to see if antioxidants in the tea leaves could help protect cells from this type of DNA damage. They found that all four types of tea extract (as well as direct application of the antioxidant EGCG) improved the outcomes for the cultured cells, with white tea extract having the strongest effect. This research suggests that tea extracts and the antioxidants that they contain may have applications in the treatment of the many diseases associated with cellular DNA damage, including cancer.

Read More...

Search Articles

Search articles by title, author name, or tags

Clear all filters

Popular Tags

Browse by school level