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Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.

Elevated acetylcholinesterase (AChE) activity contributes to cognitive decline and neurodegenerative diseases such as Alzheimer’s, motivating the search for more effective inhibitors with better bioavailability. This study used computational methods to design novel, non-toxic AChE inhibitors.

This study analyzes genetic alterations and expression patterns of protein kinases involved in phagocytosis across multiple cancers using TCGA data.

Detecting cervical spondylosis using deep learning

The authors looked at how injuries sustained during water tubing, that require treatment at an emergency department, differ between males and females.

To address the limitations in predicting the severity of Atrial Septal Defect (ASD), here the authors utilized a fluid-filled chamber model to quantify the relationship between defect size and right atrial fluid output. The findings confirmed that larger ASD diameters result in a linear increase in fluid output, validating a cost-effective model that can improve clinical prognosis and treatment planning for heart failure risks.

The authors looked at how vocabulary is impacted in Alzheimer's disease and whether it could be used a predictor of disease onset.

The authors use blood smears from individuals with sickle cell disease to correlate sickle cell frequency with the occurrence of vaso-occlusive crises.

Here the authors investigated the natural recovery of stress-induced dopamine-related gene deficits in C. elegans by measuring the expression of cat-2 (dopamine biosynthesis) and sod-2 (oxidative stress) following exposure to starvation or hydrocortisone. They found that the reversibility of sod-2 and the expression of cat-2 were highly dependent on the type and severity of the stressor, suggesting that the body's natural ability to recover from dopamine dysfunction has biological limitations.

Crohn’s disease is a chronic inflammatory bowel condition with symptoms like abdominal pain, fatigue, diarrhea, and malnutrition. Though there's no cure, various treatments help manage it. This study explored the potential impact of Massa Medicata Fermentata (MMF), a fermented Chinese herbal medicine containing Saccharomyces cerevisiae, on Crohn’s disease.