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Characterization and Phylogenetic Analysis of the Cytochrome B Gene (cytb) in Salvelinus fontinalis, Salmo trutta and Salvelinus fontinalis X Salmo trutta Within the Lake Champlain Basin

Palermo et al. | Jan 24, 2014

Characterization and Phylogenetic Analysis of the Cytochrome B Gene (<em>cytb</em>) in <em>Salvelinus fontinalis</em>,<em> Salmo trutta</em> and <em>Salvelinus fontinalis X Salmo trutta</em> Within the Lake Champlain Basin

Recent declines in the brook trout population of the Lake Champlain Basin have made the genetic screening of this and other trout species of utmost importance. In this study, the authors collected and analyzed 21 DNA samples from Lake Champlain Basin trout populations and performed a phylogenetic analysis on these samples using the cytochrome b gene. The findings presented in this study may influence future habitat decisions in this region.

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Sepia bandensis ink inhibits polymerase chain reactions

Novoselov et al. | Sep 21, 2020

<em>Sepia bandensis</em> ink inhibits polymerase chain reactions

While cephalopods play significant roles in both ecosystems and medical research, there is currently no assembled genome. In an attempt to sequence the Sepia bandensis genome, it was found that there was inhibition from the organism during DNA extraction, resulting in PCR failure. In this study, researchers tested the hypothesis that S. bandensis ink inhibits PCR. They then assessed the impact of ink on multiple methods of DNA extraction

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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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Genetic underpinnings of the sex bias in autism spectrum disorder

Lee et al. | Mar 29, 2024

Genetic underpinnings of the sex bias in autism spectrum disorder
Image credit: Louis Reed

Here, seeking to identify a possible explanation for the more frequent diagnosis of autism spectrum disorder (ASD) in males than females, they sought to investigate a potential sex bias in the expression of ASD-associated genes. Based on their analysis, they identified 17 ASD-associated candidate genes that showed stronger collective sex-dependent expression.

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Investigation of unknown causes of uveal melanoma uncovers seven recurrent genetic mutations

Nanda et al. | Aug 25, 2022

Investigation of unknown causes of uveal melanoma uncovers seven recurrent genetic mutations

Uveal melanoma (UM) is a rare subtype of melanoma but the most frequent primary cancer of the eye in adults. The goal of this study was to research the genetic causes of UM through a comprehensive frequency analysis of base-pair mismatches in patient genomes. Results showed a total of 130 genetic mutations, including seven recurrent mutations, with most mutations occurring in chromosomes 3 and X. Recurrent mutations varied from 8.7% to 17.39% occurrence in the UM patient sample, with all mutations identified as missense. These findings suggest that UM is a recessive heterogeneous disease with selective homozygous mutations. Notably, this study has potential wider significance because the seven genes targeted by recurrent mutations are also involved in other cancers.

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Detection and Control of Spoilage Fungi in Refrigerated Vegetables and Fruits

Chari et al. | May 16, 2021

Detection and Control of Spoilage Fungi in Refrigerated Vegetables and Fruits

Food spoilage leads to a significant loss in agricultural produce each year. Here, the authors investigate whether certain essential oils can protect against fungus-mediated spoilage of fruits and vegetables. Their results suggest that the compounds they tested might indeed inhibit fungal growth, at various temperatures, a promising result that could reduce food wasting.

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