The Wnt signaling pathway, known to coordinate important aspects of cellular homeostasis ranging from differentiation, proliferation, migration, and much more, is dysregulated in many human diseases. This study demonstrates that aminomethylphosphonic acid, which is the main metabolite found in the common herbicide Glyphosate, is toxic to planaria and capable of binding to canonical Wnt proteins.

This study examined the relationship between the slope of a terrain and vegetation, measured by the normalized difference vegetation index (NDVI). It was hypothesized that lower slope ranges would be more supportive of vegetation growth than higher slope ranges. Analysis showed that no slope (even as extreme as 85–90°) prohibits the growth of vegetation completely; even the steepest slopes examined contain plant life. Knowing that steep slopes can still support plant life, agriculturalists can begin to explore and start planting additional crops and plants at these extreme slopes.

Berberine is a natural quaternary alkaloid that has anti-microbial and anti-cancer effects. This compound can bind to Guanine Quadruplex (G4) DNA secondary complexes to help inhibit cancer cell proliferation. In this study, the authors investigate whether incorporating large aromatic rings helps to stabilize berberine-G4 interactions.

The authors investigated prophages present in Streptococcus bacteria that may increase their survival in different environments.

DegS is an integral inner membrane protein in E. coli that helps break down misfolded proteins. When it is mutated, there is a large increase in the production of outer membrane vesicles (OMVs), which are thought to play a role in pathogenesis. This study used mutant strains of uropathogenic E. coli (UPEC) to characterize the role of DegS and OMVs on UPEC virulence.

This study uses neuroimaging to investigate cognitive set-shifting, a type of executive function that involves shifting from one task to another. This study tested whether cortical gray-white matter contrast in subregions of the prefrontal cortex (PFC) was associated with set-shifting abilities in adults.

In this study, the authors design a series of new biaryl small molecules to target and block the binding pocket of the enzyme dihydropteroate synthase, which is important for prokaryotic biosynthesis of folic acid and could serve as better antimicrobial compounds.

In an extensive study of gene mutations, and their resulting effect on protein-protein interactions, Desai and Stork found that HTT-PRPF40B-MECP2 interactions are weakened with progression of Lopes-Maciel-Rodan syndrome.

While serving as an immediate address for psychological safety and stability, psychological first aid (PFA) currently lacks the incorporation of triage. Without triage, patients cannot be prioritized in correspondence to condition severity that is often called for within emergency conditions. To disentangle the relevance of a potential triage system to PFA, the authors of this paper have developed a method to quantify resilience - a prominent predictor of the capability to recover from a disaster. With this resilience index, they have quantified resilience of differing age, race, and sex demographics to better inform the practice of PFA and potential demographic prioritization via a triage system.

Acquired drug resistance is an increasing challenge in treating cancer with chemotherapy. One mechanism
behind this resistance is the increased inflammation that supports the progression and development of
cancer that arises because of the drug’s presence. Integrative oncology is the field that focuses on including natural products alongside traditional therapy to create a treatment that focuses on holistic patient well-being.
In this study, the authors demonstrate that the use of an herbal formulation, consisting of turmeric and green tea, alongside a traditional chemotherapeutic drug, 5-fluorouracil (FU) significantly decreases the level of cytokines produced in breast cancer cells when compared to the levels produced when exposed solely to the chemo drug. The authors conclude that this combination of treatment, based on the principle of integrative oncology, shows potential for reducing the resistance against treatment conferred through increased inflammation. Consequently, this suggests a prospective way forward in improving the efficacy of cancer treatment.