In the United States, there are currently 17.8 million affected by atopic dermatitis (AD), commonly known as eczema. It is characterized by itching and skin inflammation. AD patients are at higher risk for infections, depression, cancer, and suicide. Genetics, environment, and stress are some of the causes of the disease. With the rise of personalized medicine and the acceptance of gene-editing technologies, AD-related variations need to be identified for treatment. Genome-wide association studies (GWAS) have associated the Filaggrin (FLG) gene with AD but have not identified specific problematic single nucleotide polymorphisms (SNPs). This research aimed to refine known SNPs of FLG for gene editing technologies to establish a causal link between specific SNPs and the diseases and to target the polymorphisms. The research utilized R and its Bioconductor packages to refine data from the National Center for Biotechnology Information's (NCBI's) Variation Viewer. The algorithm filtered the dataset by coding regions and conserved domains. The algorithm also removed synonymous variations and treated non-synonymous, frameshift, and nonsense separately. The non-synonymous variations were refined and ordered by the BLOSUM62 substitution matrix. Overall, the analysis removed 96.65% of data, which was redundant or not the focus of the research and ordered the remaining relevant data by impact. The code for the project can also be repurposed as a tool for other diseases. The research can help solve GWAS's imprecise identification challenge. This research is the first step in providing the refined databases required for gene-editing treatment.
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Firearm-purchase laws that limit the number of guns on the market reduce gun homicides in the South Side of Chicago
Gun violence has been a serious issue in the South Side of Chicago for a long time. To intervene, regulators have passed legislation they hoped to curb -if not completely eradicate- the issue. However, there is little analysis done on how effective the various laws have been at reducing gun violence. Here the authors explore the association between firearm purchase laws passed between 1993-2018 and the incidence of gun homicide in Chicago's South Side. Their analysis suggests that some laws have been more effective than others, while some might have exacerbated the issue. However, they do not consider other contributing factors, which makes it difficult to prove causation without further investigation.
Read More...Stress and depression among individuals with low socioeconomic status during economic inflation
The authors use the Census Household Pulse Survey issued by the US Census Bureau to examine the prevalence of stress and depression among people across socioeconomic statuses.
Read More...The frequency and psychological effects of name mispronunciation in an independent school
The authors survey high school students regarding the frequency of microaggressions such as name mispronunciation.
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Shortage of Black physicians: Florida Black medical student enrollment from 2013 to 2021
Black patients tend to have better health outcomes when cared for by Black physicians, yet Black doctors make up only 5% of U.S. physicians, despite Black people comprising 14% of the population. This analysis of data from Florida medical schools showed a higher enrollment of Black first-year students (13.5%) compared to the national average (9%), and a national increase from 6% in 2013 to 9% in 2021, aligning with the rise of social justice movements. Increasing Black medical student enrollment could reduce health disparities and improve outcomes for Black communities.
Read More...Examining the prevalence of depression in coronary artery disease patients: a cross-sectional analysis
The authors surveyed individuals diagnosed with coronary artery disease about their mental health to study a potential connection between coronary artery disease and depression.
Read More...Income mobility and government spending in the United States
Recent research suggests that the "American Dream" of income mobility may be becoming increasingly hard to obtain. Datta and Schmitz explore the role of government spending in socioeconomic opportunity by determining which state government spending components are associated with increased income mobility.
Read More...The influence of working memory on auditory category learning in the presence of visual stimuli
Here in an effort to better understand how our brains process and remember different categories of information, the authors assessed working memory capacity using an operation span task. They found that individuals with higher working memory capacity had higher overall higher task accuracy regardless of the type of category or the type of visual distractors they had to process. They suggest this may play a role in how some students may be less affected by distracting stimuli compared to others.
Read More...Examining the relationship between screen time and achievement motivation in an adolescent population
In this study, the authors conduct a survey of high school students to evaluate the effects of screen time and habits on motivation.
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