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Berberine is a natural quaternary alkaloid that has anti-microbial and anti-cancer effects. This compound can bind to Guanine Quadruplex (G4) DNA secondary complexes to help inhibit cancer cell proliferation. In this study, the authors investigate whether incorporating large aromatic rings helps to stabilize berberine-G4 interactions.

The authors looked at the dynamics of tennis serves from professional and amateur athletes.

With low-temperature transportation being critical for the progress of research and medical services by preserving biological samples and vaccines, the optimization of cold storage materials is more critical now than ever. The exclusive use of dry ice has its limitations. Notably, it proves insufficient for cold storage during long-range transportation necessary for the delivery of specimens to rural areas. In this article, the authors have proposed a new means of cold storage through the combination of dry ice and ethanol. Upon thorough analysis, the authors have determined their new method as considerably better than the use of pure dry ice across many characteristics, including cold storage capacity, longevity of material, and financial and environmental feasibility.

The sequence of nitrogenous bases that make up the DNA of organisms can contain hidden mathematical sequences. Here the authors used BioPython, a programming tool, to find an organism that displays Gijswijt’s Sequence in its genome. In this manner they found that the common carp best displays Gijswijt’s Sequence in its genome.

Cell segmentation is the task of identifying cell nuclei instances in fluorescence microscopy images. The goal of this paper is to benchmark the performance of representative deep learning techniques for cell nuclei segmentation using standard datasets and common evaluation criteria. This research establishes an important baseline for cell nuclei segmentation, enabling researchers to continually refine and deploy neural models for real-world clinical applications.

In this study, the authors use high-throughput virtual screening to design and evaluate a set of non-nucleoside reverse transcriptase inhibitors for binding affinity to the protein reverse transcriptase. These studies have important applications toward HIV therapies.

In this study, the authors investigate the antimicrobial effects of berberine and berberine analogs. Berberine is extracted from plants and is a naturally occurring alkaloid, and is also excited photochemically. Using three different assays, the authors tested whether these compounds would inhibit bacterial growth. They found that these compounds were antibacterial and even more so when used with photoirradiation. This study has important antibacterial implications.

While cephalopods play significant roles in both ecosystems and medical research, there is currently no assembled genome. In an attempt to sequence the Sepia bandensis genome, it was found that there was inhibition from the organism during DNA extraction, resulting in PCR failure. In this study, researchers tested the hypothesis that S. bandensis ink inhibits PCR. They then assessed the impact of ink on multiple methods of DNA extraction

The authors conduct a survey to investigate the perceptions both sighted and blind people have on blindness. The results reveal both groups perceive the most challenging adversities to be the lack of awareness and understanding of their circumstances.

PVC is a widely used plastic that poses harmful health hazards when burned. In this study, the authors ask whether or not burned PVC (PVC char) affects bacterial transformation.