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Association of agenesis of the corpus callosum with epilepsy and anticonvulsant drug treatment

Steger et al. | Feb 21, 2023

Association of agenesis of the corpus callosum with epilepsy and anticonvulsant drug treatment
Image credit: Robina Weermeijer on Unsplash

Agenesis of the Corpus Callosum (ACC) is a birth defect where an infant’s corpus callosum, the structure linking the brain’s two hemispheres to allow interhemispheric communication, fails to develop in a typical manner during pregnancy. Existing research on the connection between ACC and epilepsy leaves significant gaps, due to the lack of focused investigation. One important gap is the degree to which ACC may impact the course of epilepsy treatment and outcomes. The present study was conducted to test the hypotheses that epilepsy is highly prevalent among individuals with ACC, and that those with both ACC and epilepsy have a lower response rate to anticonvulsant drugs than other patients treated with anticonvulsant drugs. A weighted average of epilepsy rates was calculated from a review of existing literature, which supported the hypothesis that epilepsy was more common among individuals with ACC (25.11%) than in the general population (1.2%). An empirical survey administered to 57 subjects or parents of subjects showed that rate of intractable epilepsy among study subjects with both ACC and epilepsy was substantially higher than the rate found in the general population, indicating that individuals with both conditions had a lower response rate to the anticonvulsant drugs. This study contributes novel results regarding the potential for concurrence of ACC and epilepsy to interfere with anticonvulsant drug treatment. We also discuss implications for how medical professionals may use the findings of this study to add depth to their treatment decisions.

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Risk assessment modeling for childhood stunting using automated machine learning and demographic analysis

Sirohi et al. | Sep 25, 2022

Risk assessment modeling for childhood stunting using automated machine learning and demographic analysis

Over the last few decades, childhood stunting has persisted as a major global challenge. This study hypothesized that TPTO (Tree-based Pipeline Optimization Tool), an AutoML (automated machine learning) tool, would outperform all pre-existing machine learning models and reveal the positive impact of economic prosperity, strong familial traits, and resource attainability on reducing stunting risk. Feature correlation plots revealed that maternal height, wealth indicators, and parental education were universally important features for determining stunting outcomes approximately two years after birth. These results help inform future research by highlighting how demographic, familial, and socio-economic conditions influence stunting and providing medical professionals with a deployable risk assessment tool for predicting childhood stunting.

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Health services in Iraq - A cross-sectional survey of adolescents in Basra

Al Saeedi et al. | Aug 12, 2022

Health services in Iraq - A cross-sectional survey of adolescents in Basra

This study is a cross-sectional survey of adolescents in Basra, Iraq, from November 2020 to March 2021 about types of adolescent problems, the individuals and institutions adolescents turn to, and the role of public health centers in dealing with their problems. The survey found that psychological problems represent the largest proportion of health problems, and most adolescents turn to their parents to discuss their problems. The work indicates that there is an urgent need to pay attention to public health centers and provide health and psychological support to adolescents.

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Giving Teens a Voice: Sources of Stress for High School Students

Corson et al. | Sep 09, 2019

Giving Teens a Voice: Sources of Stress for High School Students

The authors investigate the negative effects stress has on teen mental and physical health. Through a survey, they give Virginia teens a voice in revising the Health and Physical Education curriculum to include a standards of learning (SOL). Notably they identify factors contributing to stress levels including homework level, amount of free and sleep time, parental pressure and family encouragement.

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The effect of adverse childhood experiences on e-cigarette usage in people aged 18–30 in the US

Bloomer et al. | Oct 06, 2022

The effect of adverse childhood experiences on e-cigarette usage in people aged 18–30 in the US

Recently, e-cigarette usage has been increasing rapidly. Previous research has found that adverse
childhood experiences (ACEs) are correlated to cigarette usage. However, there is limited data exploring if ACEs affect vaping. Therefore, in this work, we investigated the effects of ACEs on e-cigarette usage and hypothesize that witnessing vaping in the house and facing ACEs would increase e-cigarette usage while education on the dangers of vaping would decrease e-cigarette usage. We found that different types of ACEs had different correlations with e-cigarette usage and that education on the dangers of vaping had no effect on e-cigarette usage.

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Socio-economic and awareness correlates of physical activity of government school children in India

Nandivada et al. | Dec 11, 2022

Socio-economic and awareness correlates of physical activity of government school children in India

Here, based on the identified importance of physical activity in the development of young children, the authors investigated the effects of socioeconomic factors on the amount of physical activity of government-school children in India. They found significant differences between boys and girls, rural and urban, and children who were encouraged to exercise and those who were not. Overall, they suggest that their findings point to the important role of schools and communities in promoting healthy active lifestyles for developing children.

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Utilizing 25-Hydroxyvitamin D3 to prevent the appearance of diabetic-like phenotypes in Drosophila melanogaster

Zaverchand et al. | Sep 20, 2021

Utilizing 25-Hydroxyvitamin D3 to prevent the appearance of diabetic-like phenotypes in Drosophila melanogaster

This study aimed to assess the role of 25-hydroxyvitamin D3 solution, at varying concentrations, in protecting vertical transmission of diabetic-like phenotypes. We hypothesized that the highest concentration of vitamin D solution (55 ng/mL) would be most effective in having a protective role. The results indicated that the hypothesis was partially supported; overall, all three concentrations of the vitamin D solution administered to the flies reared on HSDs had a protective effect, to varying extents.

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The impact of attending a more selective college on future income

Ho et al. | Oct 16, 2024

The impact of attending a more selective college on future income

Debates around legacy preferences, recruited athletes, and affirmative action in U.S. college admissions often focus on the belief that graduating from a more selective institution leads to higher future earnings. The study hypothesized a positive correlation between college selectivity and future income due to enhanced resources and opportunities.

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