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Modeling the heart’s reaction to narrow blood vessels

Athulathmudali et al. | May 22, 2023

Modeling the heart’s reaction to narrow blood vessels

Cardiovascular diseases are the largest cause of death globally, making it a critical area of focus. The circulatory system is required to make the heart function. One component of this system is blood vessels, which is the focus of our study. Our work aims to demonstrate the numeric relationship between a blood vessel's diameter and the number of pumps needed to transport blood.

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Analysis of biofertilization impacts on Pisum sativum

Holden et al. | May 18, 2023

Analysis of biofertilization impacts on <i>Pisum sativum</i>
Image credit: David Boozer

This study explored the various effects of three different produce-based biofertilizers on pea plant growth, using red apple, pear, strawberry, and control treatments. It was hypothesized that the application of fruit biomatter would increase the growth of pea plants, with the application of strawberry biomatter having the most significant effect due to strawberries containing a higher nutrient content compared to pears and apples. Analysis confirmed the hypothesis. The application of strawberry biomatter could prove to be an effective way to increase plant growth in commercial agriculture.

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Use of yogurt bacteria as a model surrogate to compare household cleaning solutions

Shukla et al. | May 07, 2023

Use of yogurt bacteria as a model surrogate to compare household cleaning solutions
Image credit: CDC

While resources on the safety of household cleaning products are plentiful, measures of efficacy of these cleaning chemicals against bacteria and viruses remain without standardization in the consumer market. The COVID pandemic has exasperated this knowledge gap, stoking the growth of misinformation and misuse surrounding household cleaning chemicals. Arriving at a time dire for sanitization standardization, the authors of this paper have created a quantifying framework for consumers by comparing a wide range of household cleaning products in their efficacy against bacteria generated by a safe and easily replicable yogurt model.

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Impact of gadodiamide (Omniscan) on a beef liver catalase ex vivo model

Hirsch et al. | Mar 10, 2023

Impact of gadodiamide (Omniscan) on a beef liver catalase <em>ex vivo</em> model
Image credit: Marcelo Leal

Here, seeking to better understand the effects of gadolinium-based contrast agents, dyes typically used for MRI scans, the authors evaluated the activity of catalase found in beef liver both with and without gadodiamide when exposed to hydrogen peroxide. They found that gadioamide did not significantly inhibit catalase's activity, attributing this lack of effects to the chelating agent found in gadodiamide.

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Machine learning-based enzyme engineering of PETase for improved efficiency in plastic degradation

Gupta et al. | Jan 31, 2023

 Machine learning-based enzyme engineering of PETase for improved efficiency in plastic degradation
Image credit: Markus Spiske

Here, recognizing the recognizing the growing threat of non-biodegradable plastic waste, the authors investigated the ability to use a modified enzyme identified in bacteria to decompose polyethylene terephthalate (PET). They used simulations to screen and identify an optimized enzyme based on machine learning models. Ultimately, they identified a potential mutant PETases capable of decomposing PET with improved thermal stability.

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