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In this study, the authors investigate the antimicrobial effects of berberine and berberine analogs. Berberine is extracted from plants and is a naturally occurring alkaloid, and is also excited photochemically. Using three different assays, the authors tested whether these compounds would inhibit bacterial growth. They found that these compounds were antibacterial and even more so when used with photoirradiation. This study has important antibacterial implications.

Bacterial infection is resurging as one of the most dangerous challenges facing the medical establishment. Americans spend about 55 to 70 billion dollars per year on antibiotics, yet these antibiotics are becoming increasingly ineffective as illness-causing bacteria gain resistance to the prescribed drugs. We tested if 11 commonly-used spices could inhibit growth of the gram-negative bacteria, E. coli, the main takeaway from these experiments is that certain spices and herbs have antibacterial effects that inhibit growth of E.coli , and these spices could show similarly promising activity towards other bacteria.

Nosocomial infections acquired in hospitals pose a risk to patients, a risk compounded by resistant microorganisms. To combat this problem, researchers have turned to bioactive compounds from medicinal plants such as the widely used neem. In the present study, researchers sought to determine the effectiveness of different neem preparations against several hospital acquired human pathogens. Neem powder in water successfully inhibited microorganism growth making it a potential agent to combat these infections.

In South Asian countries, the major cause of oral cancer is reported to be chewing paan, which is comprised of betel leaf daubed with slaked lime paste and areca nut. To investigate how paan may contribute to the onset of cancer, the authors treated two immortalized cell lines with extracts of betel leaf, areca nut, and lime and evaluated how these treatments affected cell proliferation and cell death. Initial results indicate that while betel leaf alone may inhibit cell growth, areca nut promoted cancer cell survival and proliferation, even when co-treated with betel leaf. These data suggest that areca nut could exacerbate the progression of oral cancer in humans.

Plant pathogens can cause significant crop loss each year, but controlling them with bactericides or antibiotics can be costly and may be harmful to the environment. Green tea naturally contains polyphenols, which have been shown to have some antimicrobial properties. In this study, the authors show that green tea extract can inhibit growth of the plant pathogen Pseudomonas syringae pv. tomato and may be useful as an alternative bactericide for crops.

Plants, and all other multi-cellular organisms, develop through the coordinated action of many sets of genes. The authors here investigate the genes, in a class named KNOX, potentially responsible for organizing a certain part of Aquilegia (columbine) flowers called petal spurs. Through the technique Reverse Transcription-Polymerase Chain Reaction (RT-PCR), they find that certain KNOX genes are expressed non-uniformly in petal spurs, suggesting that they may be involved, perhaps in a cell-specific manner. This research will help guide future efforts toward understanding how many beautiful flowers develop their unique shapes.

In this study, the authors share their work on improving the frame rate of videos to reduce data sent to users with both 2D and 3D footage. This work helps improve the experience for both types of footage!

The Environmental Protection Agency (EPA) reports a significant number of heavy metal-contaminated sites across the United States. To address this public health concern, rhizoremediation using microbes has emerged as a promising solution. Here, a combination of soil microbes were inoculated in the rhizosphere in soil contaminated with 500 parts per million (ppm) of lead. Results showed rhizoremediation is an effective bioremediation strategy and may increase crop productivity by converting nonarable lands into arable lands.

In this article, the authors quantify fluctuations of primary proteins found within bovine milk across four stages of lactation. Critically, these findings bear great relevance to the nutritional support of calves as well as the varying severity of symptoms of lactose intolerance.

Wound-healing involves a sequence of events, such as inflammation, proliferation, and migration of different cell types like fibroblasts. Zinc Finger CCCH-type with G-Patch Domain Containing Protein (ZGPAT), encodes a protein that has its main role as a transcription repressor by binding to a specific DNA sequence. The aim of the study was to find out whether inhibiting ZGPAT will expedite the wound healing process by accelerating cell migration. This treatment strategy can provide a key to the development of wound healing strategies in medicine and cellular biology.