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Ramifications of natural and artificial sweeteners on the gastrointestinal system

Cowen et al. | Jun 19, 2023

Ramifications of natural and artificial sweeteners on the gastrointestinal system

This study aimed to determine whether artificial sweeteners are harmful to the human microbiome by investigating two different bacteria found to be advantageous to the human gut, Escherichia coli and Bacillus coagulans. Results showed dramatic reduction in bacterial growth for agar plates containing two artificial sweeteners in comparison to two natural sweeteners. This led to the conclusion that both artificial sweeteners inhibit the growth of the two bacteria and warrants further study to determine if zero-sugar sweeteners may be worse for the human gut than natural sugar itself.

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Quantitative definition of chemical synthetic pathway complexity of organic compounds

Baranwal et al. | Jun 19, 2023

Quantitative definition of chemical synthetic pathway complexity of organic compounds

Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.

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Associations between substance misuse, social factors, depression, and anxiety among college students

Kouser et al. | Jun 12, 2023

Associations between substance misuse, social factors, depression, and anxiety among college students
Image credit: Jordan Encarnacao

Here, the authors considered the effects of relationship status and substance use on the mental health of colleges students, where they specifically examined their correlation with depression, anxiety, and the fear of missing out (FoMO). Through a survey of college students they found that those with higher substance misuse had higher levels of anxiety, depression, and FoMO, while those involved in longer-term relationships had lower levels of FoMo and alcohol use.

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The effect of sports on teenagers’ depression symptoms during the COVID-19 pandemic

Düzgezen et al. | Jun 12, 2023

The effect of sports on teenagers’ depression symptoms during the COVID-19 pandemic
Image credit: Izuddin Helmi Adnan

Here, seeking to identify the possible role of sports in helping teenagers navigate the troubles associated with societal changes during a pandemic, the authors surveyed 50 adolescents to collect Beck Depression Inventory scores. They found that 9 out of students with severe depressions did not do sports, while no significant relationship between depressive symptoms and either gender or place of exercise was observed.

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