Semantic segmentation - labelling each pixel in an image to a specific class- models require large amounts of manually labeled and collected data to train.
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The anticancer and anti-inflammatory effects of polyherbal drug AS20 on HeLa cells resistant to 5-Fluorouracil
![The anticancer and anti-inflammatory effects of polyherbal drug AS20 on HeLa cells resistant to 5-Fluorouracil](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBa1VPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--92192989c4b5409da5823bf3efcac4ab3c8cf43e/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/Figure%205(%20Pro-anti%20apoptosis)%20final%202-5-23.jpg)
The authors looked at 5-FU resistant HeLa cells and the ability of an herbal extract to show anti-inflammatory properties.
Read More...Apoptosis induction and anti-inflammatory activity of polyherbal drug AS20 on cervical cancer cell lines
![Apoptosis induction and anti-inflammatory activity of polyherbal drug AS20 on cervical cancer cell lines](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBa2dPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--0245c170d5adbda95e51ce9608b052f62ff7e6ce/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/Figure%203.jpg)
The authors found that treatment with AS20 suppressed phorbol 12-myristate 13-acetate (PMA) and 5-flurouracil (5-FU) induction of COX2 expression. We also observed AS20 treated cells showed DNA fragmentation in HeLa cells.
Read More...Estimating the liquid jet breakdown height using dimensional analysis with experimental evidence
![Estimating the liquid jet breakdown height using dimensional analysis with experimental evidence](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBak1PIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--c696b56c608ccfd730963c3a362f71c24c4f14f7/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/Screen%20Shot%202023-06-20%20at%203.23.51%20PM.png)
These authors mathematically deduce a model that explains the interesting (and unintuitive) physical phenomenon that occurs when water falls.
Read More...Evaluation of in vitro anti-inflammatory effect of PLAY® on UC-MSCs: A COX-2 expression study
![Evaluation of <i>in vitro</i> anti-inflammatory effect of PLAY® on UC-MSCs: A COX-2 expression study](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBajhPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--ecaa58c76dd694ca5e8a0ed48f34a338b99520b9/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/feature.png)
The authors seek to accelerate wound healing by reducing inflammation with a cocktail containing growth factors and bioactive modulators.
Read More...Evaluating the feasibility of SMILES-based autoencoders for drug discovery
![Evaluating the feasibility of SMILES-based autoencoders for drug discovery](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBaWtPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--f201e97491c0e9983dadf4939981766ea1281a19/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/feature.png)
The authors investigate the ability of machine learning models to developing new drug-like molecules by learning desired chemical properties versus simply generating molecules that similar to those in the training set.
Read More...Ramifications of natural and artificial sweeteners on the gastrointestinal system
![Ramifications of natural and artificial sweeteners on the gastrointestinal system](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBaXdPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--78cd69df8fac89a085976c609cc1a7d8f25c9c1b/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/Figure%202%20(2)_resized.jpg)
This study aimed to determine whether artificial sweeteners are harmful to the human microbiome by investigating two different bacteria found to be advantageous to the human gut, Escherichia coli and Bacillus coagulans. Results showed dramatic reduction in bacterial growth for agar plates containing two artificial sweeteners in comparison to two natural sweeteners. This led to the conclusion that both artificial sweeteners inhibit the growth of the two bacteria and warrants further study to determine if zero-sugar sweeteners may be worse for the human gut than natural sugar itself.
Read More...Quantitative definition of chemical synthetic pathway complexity of organic compounds
![Quantitative definition of chemical synthetic pathway complexity of organic compounds](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBakFPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--d582a6ed54d58e16b9b281ae79f59af72f9d685c/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/figure1.png)
Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.
Read More...Associations between substance misuse, social factors, depression, and anxiety among college students
![Associations between substance misuse, social factors, depression, and anxiety among college students](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBaDRPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--daca0606c7b13fb538af75390854869c755e157f/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/Homepage%20and%20feature%20image.jpg)
Here, the authors considered the effects of relationship status and substance use on the mental health of colleges students, where they specifically examined their correlation with depression, anxiety, and the fear of missing out (FoMO). Through a survey of college students they found that those with higher substance misuse had higher levels of anxiety, depression, and FoMO, while those involved in longer-term relationships had lower levels of FoMo and alcohol use.
Read More...The effect of sports on teenagers’ depression symptoms during the COVID-19 pandemic
![The effect of sports on teenagers’ depression symptoms during the COVID-19 pandemic](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBaUVPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--4e381e4dfdb49a5b51fe7a1ad7c57793596ebdba/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/Feature%20and%20homepage%20image.jpg)
Here, seeking to identify the possible role of sports in helping teenagers navigate the troubles associated with societal changes during a pandemic, the authors surveyed 50 adolescents to collect Beck Depression Inventory scores. They found that 9 out of students with severe depressions did not do sports, while no significant relationship between depressive symptoms and either gender or place of exercise was observed.
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