Higher pH level increases the efficacy of calcium phosphate-mediated intracellular delivery
This study investigated the impact of pH on the efficiency of calcium phosphate, used as a drug delivery agent.
Read More...In silico modeling of emodin’s interactions with serine/threonine kinases and chitosan derivatives
Here, through protein-ligand docking, the authors investigated the effect of the interaction of emodin with serine/threonine kinases, a subclass of kinases that is overexpressed in many cancers, which is implicated in phosphorylation cascades. Through molecular dynamics theyfound that emodin forms favorable interactions with chitosan and chitosan PEG (polyethylene glycol) copolymers, which could aid in loading drugs into nanoparticles (NPs) for targeted delivery to cancerous tissue. Both polymers demonstrated reasonable entrapment efficiencies, which encourages experimental exploration of emodin through targeted drug delivery vehicles and their anticancer activity.
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