Alcohol use disorder is a chronic, relapsing disease that affects millions of Americans every day. There are limited treatment options for alcohol dependence and alcohol withdrawal symptoms, including depression and anxiety. Previous studies have shown that probiotics can decrease depression in rodents during maternal separation and anxiety in humans. Therefore, we hypothesized that the ethanol-withdrawn planaria who consumed probiotics would have decreased withdrawal symptoms as measured by increased motility compared to the ethanol-withdrawn planaria that were not fed probiotics. The ethanol-withdrawn planaria had a statistically significant decrease in motility compared to the control group, while the planaria that consumed probiotics had no statistically significant change in motility compared to the control group.

In this study, a deep learning model is used to classify post-traumatic stress disorder patients through novel markers to assist in finding candidate biomarkers for the disorder.

Here, recognizing that alcohol manufacturers may target ethnic minorities and youths with specific forms of advertisements based on previous studies, the authors considered how alcohol storefronts differ depending on the community they are located in. Specifically, they looked at differences between Metro-Dtroit suburban communities of high- and low-incomes. They found that alcohol stores in the low-income areas had more and larger alcohol and malt liquor advertisements per store along with being within 1,000 feet of a school.

Chronic alcohol consumption can cause cardiac myopathy, which afflicts about 500,000 Americans annually. Gunturi et al. wanted to understand the effects of alcohol on heart rate and confirm the role of nitric oxide (NO) signaling in heart rate regulation. Using the model organism Daphnia magna, a water crustacean with a large, transparent heart, they found that the heart rate of Daphnia magna was reduced after treatment with alcohol. This depression could be reversed after treatment with inhibitors of NO synthesis and signaling. Their work has important implications for how we understand alcohol-induced effects on heart rate and potential treatments to reverse heart rate depression as a result of alcohol consumption.

In this article, the authors look into what is already known about the factor affecting longevity and determine the importance of behavioral factors including alcohol consumption, smoking, and obesity on longevity. The authors quantify data from over 150 countries and, interestingly, find that the impact each factor has on longevity is at least in part dependent on the country's economic development status. Overall, they conclude that an average person’s life expectancy can increase by more than 3 years if smoking and alcohol consumption is reduced by a half and weight is decreased by 10%.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder and is difficult to diagnose in young children. Here magnetoencephalography was used to compare the brain activity in patients with ASD to patients in a control group. The results show that patients with ASD have a high level of activity in different areas of the brain than those in the control group.

Diagnosing of Autism Spectrum Disorder (ASD) using tools developed in the West is challenging in the Indian setting due to a huge diversity in sociocultural and economic backgrounds. Here, the authors developed a home-based, audiovisual game app (Autest) suitable for ASD risk assessment in Indian children under 10 years of age. Ratings suggested that the tool is effective and can reduce social inhibition and facilitate assessment. Further usage and development of Autest can improve risk assessment and early intervention measures for children with ASD in India.

Major Depressive Disorder (MDD), and Post-Traumatic Stress Disorder (PTSD) are two of the fastest growing comorbid diseases in the world. Using publicly available datasets from the National Institute for Biotechnology Information (NCBI), Ravi and Lee conducted a differential gene expression analysis using 184 blood samples from either control individuals or individuals with comorbid MDD and PTSD. As a result, the authors identified 253 highly differentially-expressed genes, with enrichment for proteins in the gene ontology group 'Ribosomal Pathway'. These genes may be used as blood-based biomarkers for susceptibility to MDD or PTSD, and to tailor treatments within a personalized medicine regime.

Here, seeking to identify a possible explanation for the more frequent diagnosis of autism spectrum disorder (ASD) in males than females, they sought to investigate a potential sex bias in the expression of ASD-associated genes. Based on their analysis, they identified 17 ASD-associated candidate genes that showed stronger collective sex-dependent expression.

Here the authors investigate the use of social media in adults with Autism Spectrum Disorder (ASD) in affecting their ability and opportunities to interact with others. They found that higher usage of Internet correlated with less severe anxiety symptoms and improved social skills.