![Apoptosis induction and anti-inflammatory activity of polyherbal drug AS20 on cervical cancer cell lines](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBa2dPIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--0245c170d5adbda95e51ce9608b052f62ff7e6ce/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/Figure%203.jpg)
The authors found that treatment with AS20 suppressed phorbol 12-myristate 13-acetate (PMA) and 5-flurouracil (5-FU) induction of COX2 expression. We also observed AS20 treated cells showed DNA fragmentation in HeLa cells.
Read More...Apoptosis induction and anti-inflammatory activity of polyherbal drug AS20 on cervical cancer cell lines
The authors found that treatment with AS20 suppressed phorbol 12-myristate 13-acetate (PMA) and 5-flurouracil (5-FU) induction of COX2 expression. We also observed AS20 treated cells showed DNA fragmentation in HeLa cells.
Read More...Utilizing a Wastewater-Based Medium for Engineered Saccharomyces cerevisiae for the Biological Production of Fatty Alcohols and Carboxylic Acids to Replace Petrochemicals
Saccharomyces cerevisiae yeast is used to produce bioethanol, an alternative to fossil fuels. In this study, authors take advantage of this well studied yeast by genetically engineering them to increase fatty acid biosynthesis and culturing in a cost-effective wastewater based medium; potentially providing a sustainable alternative to petrochemicals.
Read More...Reducing PMA-induced COX-2 expression using a herbal formulation in MCF-7 breast cancer cells
In this study, the authors investigate the effect of a herbal formulation on Cyclooxygenase-2 (COX-2) expression in cancer cells. High levels of COX-2 correlates with worsened cancer outcomes and the authors hypothesize that the formulation will inhibit COX-2 levels.
Read More...Protective effect of bromelain and pineapple extracts on UV-induced damage in human skin cells
In this study, the authors tested whether the compound bromelain extracted from pineapples could protect skin cells from UV damage.
Read More...Modulation of VEGF and TGF beta in 5-FU induced inflammation in MCF-7 using an herbal formulation
Acquired drug resistance is an increasing challenge in treating cancer with chemotherapy. One mechanism
behind this resistance is the increased inflammation that supports the progression and development of
cancer that arises because of the drug’s presence. Integrative oncology is the field that focuses on including natural products alongside traditional therapy to create a treatment that focuses on holistic patient well-being.
In this study, the authors demonstrate that the use of an herbal formulation, consisting of turmeric and green tea, alongside a traditional chemotherapeutic drug, 5-fluorouracil (FU) significantly decreases the level of cytokines produced in breast cancer cells when compared to the levels produced when exposed solely to the chemo drug. The authors conclude that this combination of treatment, based on the principle of integrative oncology, shows potential for reducing the resistance against treatment conferred through increased inflammation. Consequently, this suggests a prospective way forward in improving the efficacy of cancer treatment.
Cytotoxicity evaluation of Amaranthus extracts compared with AS20 on MCF-7 cancer cells
The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.
Read More...Luteolin's positive inhibition of melanoma cell lines.
Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a flavonoid that occurs in fruits, vegetables, and herbs. Research suggests that luteolin is effective against various forms of cancer by triggering apoptosis pathways. This experiment analyzes the effects of luteolin on the cell viability of malignant melanoma cells using an in vitro experiment to research alternative melanoma treatments and hopefully to help further cancer research as a whole.
Read More...Characterization of Drought Tolerance in Arabidopsis Mutant fry1-6
In a world where water shortage is becoming an increasing concern, and where population increase seems inevitable, food shortage is an overwhelming concern for many. In this paper, the authors aim to characterize a drought-resistant strain of A. thaliana, investigating the cause for its water resistance. These and similar studies help us learn how plants could be engineered to improve their ability to flourish in a changing climate.
Read More...Fingerprint patterns through genetics
This study explores the link between fingerprints and genetics by analyzing familial fingerprints to show how the fingerprints between family members, and in particular siblings, could be very similar. The hypothesis was that the fingerprints between siblings would be very similar and the dominant fingerprint features within the family would be the same throughout the generations. Fingerprints between the siblings showed a trend of similarity, with only very small differences which makes these fingerprints unique. This work helps to support the link between fingerprints and genetics while providing a modern technological application.
Read More...Can Children Acquire Their Parents’ History of Fracture?
While the genetic basis of hip fracture risk has been studied extensively in adults, it is not known whether parental history of bone fractures affects their children's fracture risk. In this article, the authors investigated whether a parental history of bone fractures influences the rate of fractures in their children. They found that adolescent children whose parents had a more extensive history of fractures were more likely to have a history of fractures themselves, suggesting that parents' medical histories may be an important consideration in future pediatric health research.
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