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Identification of potential therapeutic targets for multiple myeloma by gene expression analysis

Kochenderfer et al. | Apr 26, 2024

Identification of potential therapeutic targets for multiple myeloma by gene expression analysis
Image credit: The authors

A central challenge of cancer therapy is identifying treatments that will effectively target cancer cells while minimizing effects on healthy cells. To identify potential targets for treating a multiple myeloma, a frequently incurable cancer, Kochenderfer and Kochenderfer analyze RNA sequencing data from the Cancer Cell Line Encyclopedia to find genes with high expression in multiple myeloma cells and low expression in normal tissues

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Mask wearing and oxyhemoglobin saturation effects during exercise

Foss et al. | Jul 15, 2022

Mask wearing and oxyhemoglobin saturation effects during exercise

Wearing face masks has become a common occurrence in everyday life and during athletics due to the spread of diseases. This study tested if masks would affect blood percent saturation of hemoglobin (SpO2) during treadmill exercise. The data analysis showed that mask type, time, and the interaction of mask type and time were significant results, regardless of physical ability. These results may assist athletes in understanding the differences between training and competing with and without a mask.

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Focusing Sound Waves Using a Two-Dimensional Non-Linear System

Wehr et al. | Jul 07, 2014

Focusing Sound Waves Using a Two-Dimensional Non-Linear System

Sound waves can be amazingly powerful, especially when they work together. Here the authors create an “acoustic lens” that focuses sound waves on a single location. This makes the sound waves very powerful, capable of causing damage at a precise point. In the future, acoustic lenses like this could potentially be used to treat cancer by killing small tumors without surgery.

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Prediction of preclinical Aβ deposit in Alzheimer’s disease mice using EEG and machine learning

Igarashi et al. | Nov 29, 2022

Prediction of preclinical Aβ deposit in Alzheimer’s disease mice using EEG and machine learning

Alzheimer’s disease (AD) is a common disease affecting 6 million people in the U.S., but no cure exists. To create therapy for AD, it is critical to detect amyloid-β protein in the brain at the early stage of AD because the accumulation of amyloid-β over 20 years is believed to cause memory impairment. However, it is difficult to examine amyloid-β in patients’ brains. In this study, we hypothesized that we could accurately predict the presence of amyloid-β using EEG data and machine learning.

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The Effects of Atmospheric Attenuation on Cosmic Ray Muons: How is Surface Level Cosmic Ray Muon Flux Affected by Atmospheric Attenuation?

Sun et al. | Sep 11, 2021

The Effects of Atmospheric Attenuation on Cosmic Ray Muons: How is Surface Level Cosmic Ray Muon Flux Affected by Atmospheric Attenuation?

Cosmic rays are high-energy astronomical particles originating from various sources across the universe. Here, The authors sought to understand how surface-level cosmic-ray muon flux is affected by atmospheric attenuation by measuring the variation in relative muon-flux rate relative to zenith angle, testing the hypothesis that muons follow an exponential attenuation model. The attenuation model predicts an attenuation length of 6.3 km. This result implies that only a maximum of 24% of muons can reach the Earth’s surface, due to both decay and atmospheric interactions.

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The knowledge and perception of opioid abuse and its long-term effects among high schoolers

Shroff et al. | Nov 27, 2021

The knowledge and perception of opioid abuse and its long-term effects among high schoolers

Due to the susceptibility of adolescent age groups to opioid misuse, here the authors sought to determine if there was a difference in the perception and knowledge between 9th and 12th graders regarding the opioid crisis. An educational intervention trial was done with the 9th graders and surveys were used to identify its effects. Although the authors acknowledge a small sample size, their results suggest that their are gaps within the knowledge of adolescents in regards to opioid misuse and its long-term effects that could be addressed with further education.

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