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Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Sun et al. | Dec 18, 2020

Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.

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The Effect of Wind Mitigation Devices on Gabled Roofs

Kaufman et al. | Feb 20, 2021

The Effect of Wind Mitigation Devices on Gabled Roofs

The purpose of this study was to test devices installed on a gabled roof to see which reduced the actual uplift forces best. Three gabled birdhouse roofs were each modified with different mitigation devices: a rounded edge, a barrier shape, or an airfoil. The barrier edge had no significant effect on the time for the roof to blow off. The addition of airfoil devices on roofs, specifically in areas that are prone to hurricanes such as Florida, could keep roofs in place during hurricanes, thus reducing insurance bills, overall damage costs, and the loss of lives.

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Sports Are Not Colorblind: The Role of Race and Segregation in NFL Positions

Coleman et al. | Oct 23, 2018

Sports Are Not Colorblind: The Role of Race and Segregation in NFL Positions

In this study, the authors conducted a statistical investigation into the history of position-based racial segregation in the NFL. Specifically, they focused on the cornerback position, which they hypothesized would be occupied disproportionately by black players due to their historical stereotyping as more suitable for positions requiring extreme athletic ability. Using publicly available datasets on the demographics of NFL players over the past several decades, they confirmed their hypothesis that the cornerback position is skewed towards black players. They additionally discovered that, unlike in the quarterback position, this trend has shown no sign of decreasing over time.

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