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The Protective Effects of Panax notoginseng Saponin on the Blood-Brain Barrier via the Nrf2/ARE Pathway in bEnd3 Cells

Yang et al. | Apr 06, 2016

The Protective Effects of <i>Panax notoginseng</i> Saponin on the Blood-Brain Barrier via the Nrf2/ARE Pathway in bEnd3 Cells

Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.

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Investigation of unknown causes of uveal melanoma uncovers seven recurrent genetic mutations

Nanda et al. | Aug 25, 2022

Investigation of unknown causes of uveal melanoma uncovers seven recurrent genetic mutations

Uveal melanoma (UM) is a rare subtype of melanoma but the most frequent primary cancer of the eye in adults. The goal of this study was to research the genetic causes of UM through a comprehensive frequency analysis of base-pair mismatches in patient genomes. Results showed a total of 130 genetic mutations, including seven recurrent mutations, with most mutations occurring in chromosomes 3 and X. Recurrent mutations varied from 8.7% to 17.39% occurrence in the UM patient sample, with all mutations identified as missense. These findings suggest that UM is a recessive heterogeneous disease with selective homozygous mutations. Notably, this study has potential wider significance because the seven genes targeted by recurrent mutations are also involved in other cancers.

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Dune flora can emerge from seed islands (Concon, Chile)

Farías Giusti-Bilz et al. | Dec 07, 2020

Dune flora can emerge from seed islands (Concon, Chile)

In the field of ecology, little is known about how plant communities originate. Through the process of characterizing dunes, mounds of sand formed by the wind, and their plant communities we can get to know the physiognomy and floristic composition of the territory. Based on the hypothesis that dune flora can emerge from seed islands: holes in the sand 6 cm deep containing a mixture of seeds, broken branches of shrubbery, and rabbit feces, during spring, the authors determined the composition of 20 seed islands in the sand dunes of Concon, Chile and measured how many seeds germinated in each one.

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The Effects of Barley Straw (Hordeum vulgare) Extract and Barley Straw Pellets on Algal Growth and Water Quality

McHargue et al. | Oct 06, 2020

The Effects of Barley Straw (Hordeum vulgare) Extract and Barley Straw Pellets on Algal Growth and Water Quality

Algal overgrowth often threatens to clog irrigation pipes and drinking water lines when left unchecked, as well as releasing possible toxins that threaten plant and human health. It is thus important to find natural, non-harmful agents that can decrease algal growth without threatening the health of plants and humans. In this paper, the authors test the efficacy of barely extract in either liquid or pellet form in decreasing algal growth. While their results were inconclusive, the experimental set-up allows them to investigate a wider range of agents as anti-algal treatments that could potentially be adopted on a wider scale.

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