The independent effects of metastasis-promoting gene CD151 in the process of metastasis are not known. This study aimed to isolate CD151 to discover what its role in metastasis would be uninfluenced by potential interactions with other components and pathways in human cells. Results showed that CD151 significantly increased the adhesion of the cells and decreased their motility. Thus, it may be that CD151 is upregulated in cancer cells for the last step of metastasis, and it increases the chances of success of metastasis by aiding in implantation of the cancer cells. Targeting CD151 in chemotherapeutic modalities could therefore potentially slow or prevent metastasis.

In this study, the authors explored whether students' test scores were significantly higher on online exams during the COVID-19 school lockdown when compared to those of the in-person exams before the lockdown.

Chronic alcohol consumption can cause cardiac myopathy, which afflicts about 500,000 Americans annually. Gunturi et al. wanted to understand the effects of alcohol on heart rate and confirm the role of nitric oxide (NO) signaling in heart rate regulation. Using the model organism Daphnia magna, a water crustacean with a large, transparent heart, they found that the heart rate of Daphnia magna was reduced after treatment with alcohol. This depression could be reversed after treatment with inhibitors of NO synthesis and signaling. Their work has important implications for how we understand alcohol-induced effects on heart rate and potential treatments to reverse heart rate depression as a result of alcohol consumption.

In this study, the authors test new antimicrobials by measuring the ability of extracts from Australian-native Myrtaceae species to induce death of two bacteria S. aureus and P. aeruginosa.

In this study, the authors test different infill patterns to determine which would be the strongest and most durable for 3D printing applications, which have become an integral part of many facets of life.

This study compares different methods for cooking vegetables to determine which retain iron and ascorbic acid, or vitamin C, levels the most.

Sadly, around 800,000 people die by suicide worldwide each year. Dong and Pearce analyze health survey data to identify associations between suicidal ideation and relevant variables, such as sleep quality, hopelessness, and anxious behavior.

In this article the authors looked at how temperature was impacted when alumnium was added in various forms to aqueous copper(II) solutions. Their study investigates the impact of surface area on chemical reactions.

Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.

One-third of the world's people do not have access to clean drinking water. Nadella and Nadella tackle this issue by testing a low-cost filtration system for removing heavy metal and bacteria from water.